Top 5 Japanese Companies To Watch In Right Now

NEW YORK ��As 2013 comes to a close, efforts to revive growth in the world�� most influential economies ��with the exception of the eurozone ��are having a beneficial effect worldwide. All of the looming problems for the global economy are political in character.

After 25 years of stagnation, Japan is attempting to reinvigorate its economy by engaging in quantitative easing on an unprecedented scale. It is a risky experiment: faster growth could drive up interest rates, making debt-servicing costs unsustainable. But Prime Minister Shinzo Abe would rather take that risk than condemn Japan to a slow death. And, judging from the public�� enthusiastic support, so would ordinary Japanese.

By contrast, the European Union is heading toward the type of long-lasting stagnation from which Japan is desperate to escape. The stakes are high: Nation-states can survive a lost decade or more; but the EU, an incomplete association of nation-states, could easily be destroyed by it.

Hot Japanese Stocks To Buy Right Now: Rudolph Technologies Inc.(RTEC)

Rudolph Technologies, Inc. designs, develops, manufactures, and sells process control defect inspection, metrology, and process control software systems to microelectronics device manufacturers. The company provides yield management solutions for use in wafer processing and final manufacturing through a range of standalone systems for macro-defect inspection, test systems, and transparent and opaque thin film measurements. It also offers a range of process control software solutions for semiconductor, solar, and LED manufacturing. It provides products for various applications in the areas of macro-defect detection and classification, diffusion, etch, lithography, CVD, PVD, and CMP. The company sells its products and solutions to logic, memory, data storage, and application-specific integrated circuit device manufacturers. It sells its products in the United States, Taiwan, China, Singapore, South Korea, Japan, and Europe. The company was founded in 1940 and is based in Fla nders, New Jersey.

Advisors' Opinion:

• [By John Emerson]

  Orbotech (ORBK) and Rudolph Technologies (RTEC) Sizable Net-Nets in the AOI Sector

  As noted previously, I rode the elevator up and then back down on Camtek (CAMT), a tiny Israeli automated optical inspection (AOI) company. By late 2008 the company had fallen to below $1 per share. Both of Camtek�� larger rivals, RTEC and ORBK, had dropped to absurdly low levels by November 2008. I used the opportunity to switch out of CAMT and some of my other losing propositions in favor of these superior companies. In the process, I created a large amount of tax loss carry-forwards which would allow me to minimize my future taxation when I decided to sell these cyclical entities.

• [By Seth Jayson]

  Basic guidelines
  In this series, I examine inventory using a simple rule of thumb: Inventory increases ought to roughly parallel revenue increases. If inventory bloats more quickly than sales grow, this might be a sign that expected sales haven't materialized. Is the current inventory situation at Rudolph Technologies (Nasdaq: RTEC  ) out of line? To figure that out, start by comparing the company's inventory growth to sales growth. How is Rudolph Technologies doing by this quick checkup? At first glance, not so great. Trailing-12-month revenue increased 17.6%, and inventory increased 32.2%. Comparing the latest quarter to the prior-year quarter, the story looks potentially problematic. Revenue dropped 8.9%, and inventory grew 32.2%. Over the sequential quarterly period, the trend looks worrisome. Revenue dropped 23.3%, and inventory grew 10.8%.

• [By Seth Jayson]

  When judging a company's prospects, how quickly it turns cash outflows into cash inflows can be just as important as how much profit it's booking in the accounting fantasy world we call "earnings." This is one of the first metrics I check when I'm hunting for the market's best stocks. Today, we'll see how it applies to Rudolph Technologies (Nasdaq: RTEC  ) .

Top 5 Japanese Companies To Watch In Right Now: Templeton Emerging Markets Fund (EMF)

Templeton Emerging Markets Fund (the Fund) is a diversified, closed-end investment company. The Fund seeks long-term capital appreciation by investing at least 80% of its net assets in emerging country equity securities. It makes investments in China, Brazil, South Korea, Turkey, Russia, Thailand, India, Taiwan, Hungary and South Africa. The Fund invests in sectors, such as metals and mining, commercial banks, diversified financial services, semiconductors and semiconductor equipment, wireless telecommunication services, and oil, gas and consumable fuels.

Templeton Asset Management Ltd. (TAML) serves as the Fund�� investment manager. Its administrative manager is Franklin Templeton Services, LLC. The Fund may invest in the Franklin Institutional Fiduciary Trust Money Market Portfolio (the Sweep Money Fund), an open-end investment company managed by Franklin Advisers, Inc. (an affiliate of TAML).

Advisors' Opinion:

• [By George Putnam, Editor, New Generation Research, Inc.]

  Templeton Emerging Markets Fund (EMF) is also actively managed. Currently, the fund is Asian-centric with about 71% of assets from Asian markets, mostly China and Thailand.

Top 5 Japanese Companies To Watch In Right Now: Cameron International Corp (CAM)

Cameron International Corporation (Cameron), incorporated on November 10, 1994, provides flow equipment products, systems and services to worldwide oil, gas and process industries. Cameron operates in three business segments: Drilling and Production Systems (DPS), Valves & Measurement (V&M) and Process & Compression Systems (PCS). The DPS segment includes businesses, which provides systems and equipment used to control pressures and direct flows of oil and gas wells. The V&M segment includes businesses, which provides valves and measurement systems used to control, direct and measure the flow of oil and gas as they are moved from individual wellheads through flow lines, gathering lines and transmission systems to refineries, petrochemical plants and industrial centers for processing. The PCS segment includes businesses, which provides standard and custom-engineered process packages for separation and treatment of impurities within oil and gas and compression equipment and aftermarket parts and services to the oil, gas and process industries. During the year ended December 31, 2011, it acquired LeTourneau Technologies, Inc. (LeTourneau) from Joy Global Inc. During 2011, it acquired Vescon Equipamentos Industrias Ltda. During 2011, it acquired 51% interest in Newmans Valves. In September 2012, TTS Group ASA sold its drilling equipment business to the Company. Effective August 5, 2013, Cameron International Corp acquired a 75% interest in Douglas Chero SpA, from Consilium SGR SpA.

Drilling & Production Systems Segment

Cameron�� products are employed in a range of operating environments, including basic onshore fields, complex onshore and offshore environments, deepwater subsea applications and ultra-high temperature geothermal operations. The products within this segment include surface and subsea production systems, blowout preventers (BOPs), drilling and production control systems, block valves, gate valves, actuators, chokes, wellheads, manifolds, drilling risers, top drive! s, mud pumps, other rig products and aftermarket parts and services. In addition, the DPS segment designs and manufactures structural components for land and offshore drilling rigs. The segment�� businesses also manufacture elastomers, which are used in pressure and flow control equipment and other petroleum industry applications, as well as in the petroleum, petrochemical, rubber molding and plastics industries. The businesses within this segment market their products directly to end-users through a worldwide network of sales and marketing employees, supported by agents in some international locations. Customers include oil and gas majors, national oil companies, independent producers, engineering and construction companies, drilling contractors, rental companies and geothermal energy producers. The businesses included in this segment are Drilling Systems, Surface Systems, Subsea Systems and Flow Control.

Drilling Systems is a global supplier of integrated drilling systems for onshore and offshore applications. Drilling equipment designed and manufactured includes ram and annular BOPs, control systems, drilling risers, drilling valves, choke and kill manifolds, diverter systems, top drives, draw works, mud pumps, other rig products and aftermarket parts and services. The products are marketed under the Cameron, Guiberson, H&H CUSTOM, H&H, Melco, LeTourneau, Lewco, OEM and Townsend brand names. Surface Systems is a global market in supplying surface production equipment, from conventional to high-pressure, high temperature (HPHT) wellheads, production systems and controls, block valves, gate valves, mudline systems, dry completion systems and aftermarket parts and services. The products are marketed under the Cameron, Camrod, IC, McEvoy, Precision, SBS, Tundra, Willis and WKM brand names. Cameron, which has a global base of installed equipment and an aftermarket presence in hydrocarbon-producing region worldwide, is the provider of surface production equipment. Surface Systems added new s! ales and ! aftermarket facilities in the Marcellus, Eagle Ford and Haynesville shale regions.

Subsea Systems is a provider of subsea wellheads, production systems and controls, manifolds and aftermarket parts and services to customers worldwide, from basic subsea tree orders to integrated solutions, as well as installation and aftermarket support. These products are marketed under the Cameron, Mars, McEvoy and Willis brand names. Flow Control provides chokes, actuators, gears, valve accessories and automation solutions to other Cameron businesses, as well as to other industry manufacturers and directly to end users under such brand names as Cameron, Dynatorque, Ledeen, Maxtorque, Test and Willis. Flow Control has expanded its subsea chemical injection metering valve (CIMV) product line, introducing a high-flow CIMV.

Valves & Measurement Segment

Cameron�� products include gate valves, ball valves, butterfly valves, Orbit valves, double block & bleed valves, plug valves, globe valves, check valves, actuators, chokes and aftermarket parts and services, as well as measurement products such as totalizers, turbine meters, flow computers, chart recorders, ultrasonic flow meters and sampling systems. This equipment and the related services are marketed through a worldwide network of combined sales and marketing employees, as well as distributors and agents in selected international locations. Customers include oil and gas majors, independent producers, engineering and construction companies, pipeline operators, drilling contractors and major chemical, petrochemical and refining companies. The businesses included in this segment are Distributed Valves, Engineered Valves, Process Valves, Measurement Systems and Aftermarket Services.

Distributed Valves provides a range of valves used in the exploration, production and transportation of oil and gas, with products sold through a network of wholesalers and distributors, primarily in North America and to upstream markets in A! sia-Pacif! ic and the Middle East. These valves are marketed under the brand names Cooper, Demco, Navco, Newco, Nutron, OIC, Techno, Texstream, Thornhill Craver, Wheatley and WKM. Engineered Valves provides a range of customized ball, gate and check valves serving the oil and gas production, pipeline, subsea and liquefied natural gas (LNG) markets. Products are marketed under the brand names Cameron, Entech, Grove, Ring-O, TK and Tom Wheatley.

Process Valves provides valves under the brand names of General Valve, Orbit, TBV and WKM for use in critical service applications that are often subject to extreme temperature conditions, particularly in refinery, power generation, including nuclear, chemical, petrochemical, gas processing and liquid storage terminal markets, including liquefied natural gas (LNG). Measurement Systems designs, manufactures and distributes measurement products, systems and solutions to the global oil and gas, process and power industries. The Company�� main product brand names include Barton, Caldon, Clif Mock, Jiskoot, Linco, Nuflo and PAAI. Aftermarket Services provides preventative maintenance, original equipment manufacturer (OEM) spare parts, repair, field service, asset management and remanufactured products for valves and actuators.

Process & Compression Systems Segment

Integrally geared centrifugal compressors are used by customers worldwide in a range of industries, including air separation, petrochemical, chemical and process gas. Products include oil and gas separation equipment, heaters, dehydration and desalting units, gas conditioning units, membrane separation systems, water processing systems, integral engine-compressors, separable reciprocating compressors, two and four-stroke cycle gas engines, turbochargers, integrally-geared centrifugal compressors, compressor systems and controls. Aftermarket services include spare parts, technical services, repairs, overhauls and upgrades. The businesses included in this segment are Process System! s, Recipr! ocating Compression and Centrifugal Compression.

The process systems businesses provide custom-engineered process packages to oil and gas majors, national oil companies, independent operators and engineering, procurement and construction companies worldwide for separation and treatment of oil, gas, water and solids. Products offered include separators, heaters, dehydration and desalting units, gas conditioning units, membrane separation systems, water processing systems and aftermarket parts and services. PCS markets its process systems products under the Cameron, Consept, Cynara, Hydromation, KCC, Metrol, Mozley, NATCO, Petreco, Porta-test, Unicel, Vortoil and Wemco brand names.

Reciprocating Compression equipment is used throughout the energy industry by gas transmission companies, compression leasing companies, oil and gas producers and independent power producers. Reciprocating Compression products and services are marketed under the Ajax, Cooper-Bessemer, CSI, Enterprise, Superior, Texcentric and TSI brand names. Ajax integral engine-compressors, which combine the engine and compressor on a single drive shaft, are used for gas re-injection and storage, as well as on smaller gathering and transmission lines. Superior-brand separable compressors are used for natural gas applications, including production, storage, withdrawal, processing and transmission, as well as petrochemical processing. These high-speed separable compressor units can be matched with either natural gas engine drivers or electric motors. Reciprocating Compression also provides global support for its products and maintains sales and service offices in key international locations. During 2011, approximately 60% of the Reciprocating Compression revenues were generated by sales of aftermarket parts and services in support of the Company�� worldwide installed base of compression equipment. Customers for Reciprocating Compression products include oil and gas majors, national oil companies, petrochemical and re! fining co! mpanies, midstream natural gas companies, independent power producers and compressed natural gas distribution companies.

Centrifugal Compression manufactures and supplies integrally geared centrifugal compressors and provides aftermarket services to customers worldwide. Centrifugal air compressors, used in manufacturing processes (plant air), are sold under the Turbo-Air. Engineered compressors are used in the process air and gas industries and are identified by the MSG. The process and plant air centrifugal compressors deliver oil-free compressed air and other gases to customers, thus preventing oil contamination of the finished products. Centrifugal Compression also provides installation and maintenance services, parts, repairs, overhauls and upgrades to its worldwide customers for plant air and process gas compressors. It also provides aftermarket service and repairs on all equipment it produces through a worldwide network of distributors, service centers and field service technicians utilizing an extensive inventory of parts marketed under the Joy brand name. Centrifugal Compression customers include oil and gas majors, national oil companies, air separation companies, independent power producers, petrochemical and refining companies, midstream natural gas companies and durable goods manufacturers.

The Company competes with Aker Solutions, Balon Corporation, Circor International, Inc., Dover Corporation, Dril-Quip, Inc., Emerson Process Management, FlowServ Corp., FMC Technologies, Inc., GE Oil & Gas Group, Stream-Flo Industries Ltd., National Oilwell Varco Inc., Zy-Tech Global Industries company, Flotek Industries, Inc., Pibiviese, Robbins & Myers Fluid Management Group, SPX Corporation�� Flow Technology Segment, Tyco International Ltd., Weatherford, Ltd., Ariel Corporation, Compressor Engineering Corporation, Demag, Dresser-Rand Company, FS-Elliott Company LLC, Endyn Energy Dynamics, Hoerbiger Group and IR Air Solutions.

Advisors' Opinion:

• [By Benjamin Shepherd]

  Why is there such a disconnect between oil and gasoline prices? Despite the fact that oil and gasoline make just about everything go and demand has been steadily rising for decades now, oil production has had difficulty keeping pace. And since 2005 most production growth has come from the increased exploitation of shale formations and hydraulic fracturing.
  
  Since 2005, global production of crude oil has grown by 2.3 million barrels per day (MBPD) and over that same time period U.S. production of shale oil has grown by 3.5 MBPD. Not only is the U.S. essentially responsible for all the production global production growth since 2005, it has also made up from 1.2 MPBD of lost production elsewhere in the world.
  
  While the gasoline price spike since October can be largely attributed to seasonal factors ��traveling increases in the holiday and summer seasons ��tight global oil production could result in higher gasoline prices becoming a fact of life. Here in the U.S. nearly 75 percent of the oil we consume goes to transportation and higher gasoline and other distillate prices are the only effect mechanism for rationing it.
  
  That pricing mechanism, coupled with rapid advancements in drilling technologies and know-how, has also made it economical to produce once-untouchable oil reserves, such as those in deepwater or in shale formations and oil sands. It has also driven a huge push to increase global oil production in the coming years and created an opportunity to not only profit from the energy boom but also hedge your portfolio against the damaging impact of energy inflation.
  
  One interesting play on that theme is Cameron International (NYSE: CAM). Cameron provides separation and pressure control equipment, flow control, compressors, valves and other equipment to the global energy industry, as well as the services to install and maintain it. About 20 percent of its $2.4 billion in first quarter revenue was generated through equipment and serv

• [By David Smith]

  Cameron International� (NYSE: CAM  )
  As with many oil-field service companies, Houston-based Cameron International is the survivor of several mergers. Today, Cameron manufactures a host of valves, pumps, wellheads, risers and other equipment used in drilling and production. Perhaps more importantly, it makes components for land and offshore rigs, along with subsea production systems and all-important blowout preventers.

Top 5 Japanese Companies To Watch In Right Now: Market Vectors Brazil Small-Cap ETF (BRF)

Market Vectors Brazil Small-Cap ETF (the Fund) seeks to replicate as closely as possible the price and yield performance of the Market Vectors Brazil Small-Cap Index (the Index). The Index is a rules-based, modified market capitalization-weighted, float-adjusted index consisting of publicly traded small-capitalization companies that are domiciled and primarily listed on an exchange in Brazil, or that generate at least 50% of their revenues in Brazil. The Index is the exclusive property of 4asset-management GmbH, which has contracted with Standard & Poor��, a division of The McGraw-Hill Companies, Inc. to maintain and calculate the Index. The Fund is passively managed and may not hold each Index component in the same weighting as the Index. The Fund�� investment advisor is Van Eck Associates Corporation. Advisors' Opinion:

• [By Jon C. Ogg]

  Market Vectors Brazil Small-Cap ETF (NYSEArca: BRF) has performed closely with the larger ETF group, with a drop of almost 4% so far in 2014. By its name, you can assume it tracks small-cap stocks. It aims to track the Market Vectors Brazil Small-Cap Index. At $28.51, its 52-week trading range is $27.99 to $44.17.

• [By Hilary Kramer]

  Brasil Foods SA (BRF) is South America�� largest food processing company, involved in everything from meat and dairy products to pasta, frozen vegetables and soybean-related products. The company has been around since 1939, and Forbes ranked it 39th on its list of the world�� most innovative companies. It brings in about $13 billion in sales each year, and analysts are estimating that earnings will grow from 94 cents per share in 2012 to $1.94 for all of 2013, with additional growth to $2.78 in 2014.

Top 5 Freight Stocks To Buy Right Now

The Malaysian Airlines plane that has disappeared on a scheduled flight from Kuala Lumpur to Beijing is a 777-200ER from Boeing (BA). The 777 family of planes itself is Boeing's best selling dual-aisle, two-engine plane. Through the end of February Boeing has delivered a total of 422 of the 777-200ERs including 15 to Malaysian Airlines. Of 370 planes on order from the 777 family, none is a 777-200ER.

The company delivered its first 777-200 to United Airlines in May 1995, and the plane went into service the following month. The first extended range model, the 777-200ER, was delivered to and put into service by British Airways in February 1997. At list price today, the 777-200ER would cost $261.5 million and would be the lowest priced model of the 777 family.

Boeing's order book currently includes 257 new 777-300ER models; 44 777F freighters; and 66 777X models. The list price for the 777-300ER is $320.2 million. That's nearly $71 million more than the two-engine 787-9 which Boeing announced last summer and for which the company has taken orders for 404 planes.

Top 5 Services Companies To Own In Right Now: Agility Public Warehousing Co KSC (AGLTY)

Agility Public Warehousing Company KSC is a Kuwait-based company engaged, along with its subsidiaries, in the provision of global integrated logistics solutions. The Company is organized into two business segments: the Logistic and Related services segment provides logistics offering to its clients, including freight forwarding, transportation, contract logistics, project logistics and fairs and events logistics, and the Infrastructure segment provides other services, which include industrial real estate airport and airplane ground handling and cleaning services, customs consulting, private equity and waste recycling. The Company operates under the brand name of Agility. The Company�� subsidiaries include Global Express Transport Co. WLL, PWC Transport Company WLL, Agility DGS Logistics Services KSCC and Gulf Catering Company for General, among others. Advisors' Opinion:

• [By Fiona MacDonald]

  The Kuwait SE Price Index rose for a sixth day, climbing 0.5 percent to 6,851.17 at the close. Kuwait Real Estate Co. (KRE) climbed to the highest level in a month. Agility (AGLTY) advanced 1.7 percent after winning a $190 million UN contract in Sudan�� Darfur region. The Bloomberg GCC 200 Index, which tracks the biggest 200 companies in the Gulf Cooperation Council, fell 0.1 percent.

Top 5 Freight Stocks To Buy Right Now: Vitran Corporation Inc (VTNC)

Vitran Corporation Inc. (Vitran), incorporated on April 29, 1981, is a provider of freight surface transportation and related supply chain services throughout Canada 34 states in the eastern, southeastern, central, southwestern, and western United States. The Company�� business consists of Less-than-truckload services (LTL). These services are provided by stand-alone business units within their respective regions. Vitran�� business is carried on through its subsidiaries, which hold the licenses and permits required to carry on business. As of December 31, 2012, Vitran�� principal wholly owned operating subsidiaries included Vitran Express Canada Inc. (Ontario), Can-Am Logistics Inc. (Ontario), Vitran Logistics Ltd. (Ontario), Expediteur T.W. Ltee (Canada), Vitran Corporation (Nevada), Vitran Express Inc. (Pennsylvania), Vitran Logistics Corp. (Delaware), Vitran Logistics Inc. (Indiana), and Las Vegas/L.A. Express, Inc. (California). In March 2013, Vitran Corp Inc completed divestiture of its Supply Chain Operation division to Legacy Supply Chain. In October 2013, Vitran Corporation Inc. completed the sale of its United States LTL business.

LTL Services

Within Canada, the Company provides next-day service within Ontario, Quebec and parts of western Canada, and generates its revenue from the movement of LTL freight within the three- to five-day east-west service lanes. The majority of its trans-Canada freight is shipped intermodally, whereby the Company�� containers are loaded onto rail cars and trans-loaded to Vitran facilities where Vitran�� network of owner operators pick up and deliver the freight to various destinations. During 2012, Vitran�� Canadian LTL business represented approximately 27.6% of total LTL revenues. Vitran�� Transborder Service Solution (inter-regional) provides over-the-road service between its Canadian LTL and United States LTL business units.

Advisors' Opinion:

• [By Monica Gerson]

  Breaking news

  Vitran Corporation (NASDAQ: VTNC) announced today that it has entered into a definitive arrangement agreement with TransForce pursuant to which TransForce has agreed to acquire all of the outstanding common shares of Vitran not already owned by TransForce for US$6.50 in cash per share, in accordance with TransForce's prior proposal. To read the full news, click here. ReneSola (NYSE: SOL) today announced it signed a Memorandum of Intent (MOI) to sell three utility-scale projects in Western China, with a total capacity of 60MW, to Jiangsu Akcome Solar Science & Technology Co on December 30, 2013. To read the full news, click here. Cooper Tire & Rubber Company (NYSE: CTB) today announced it has terminated the merger agreement with Apollo Tyres (NSE:ApolloTYRE). To read the full news, click here. RedHill Biopharma (NASDAQ: RDHL) today announced that it has entered into a definitive agreement with leading healthcare investor OrbiMed Israel Partners Limited Partnership, an affiliate of OrbiMed Advisors LLC, for the sale of RedHill's American Depository Shares and warrants in a private placement transactionor a total sum of $6.0 million. To read the full news, click here.

  Posted-In: Guggenheim US Stock FuturesNews Eurozone Futures Global Pre-Market Outlook Markets

Top 5 Freight Stocks To Buy Right Now: Heartland Express Inc (HTLD)

Heartland Express, Inc. (Heartland), incorporated on August 8, 1986, is a short-to-medium haul truckload carrier. The Company provides regional dry van truckload services through its regional terminals plus its corporate headquarters. The Company transports freight for shippers and generally earns revenue based on the number of miles per load delivered. The Company�� primary traffic lanes are between customer locations east of the Rocky Mountains. The Company is a holding company of Heartland Express Inc. of Iowa, Heartland Express Services, Inc., Heartland Express Maintenance Services, Inc. and A & M Express, Inc. Heartland operates nine specialized regional distribution operations in Atlanta, Georgia; Carlisle, Pennsylvania; Chester, Virginia; Columbus, Ohio; Jacksonville, Florida; Kingsport, Tennessee; Olive Branch, Mississippi; Phoenix, Arizona, and Seagoville, Texas. The Company operates maintenance facilities at all regional distribution operating centers along with shop only locations in Fort Smith, Arkansas and O��allon, Missouri. In November 2013, Heartland Express Inc acquired 100% of the stock of Gordon Trucking, Inc.

The Company�� operations department is responsible for maintaining the continuity between the customer�� needs and Heartland�� ability to meet those needs by communicating customer�� expectations to the fleet management group. They are charged with development of customer relationships, ensuring service standards, coordinating proper freight-to-capacity balancing, trailer asset management, and daily tactical decisions pertaining to matching the customer demand with the appropriate capacity within geographical service areas. They assign orders to drivers based on well-defined criteria, such as driver safety and United States Department of Transportation (the DOT) compliance, customer needs and service requirements, on-time service, equipment utilization, driver time at home, operational efficiency, and equipment maintenance needs. Fleet management is r! esponsible for driver management and development. Their responsibilities include meeting the needs of the drivers within the standards that have been set by the organization and communicating the requirements of the customers to the drivers on each order to ensure successful execution. Serving the short-to-medium haul market (500 miles average length of haul in 2012) permits the Company to use primarily single, rather than team drivers and dispatch loads directly from origin to destination without an intermediate equipment change other than for driver scheduling purposes.

Advisors' Opinion:

• [By CRWE]

  Heartland Express, Inc. (Nasdaq:HTLD) reported that on Wednesday, May 30, 2012, members of its management team will participate in the 2012 KeyBanc Capital Markets Industrial, Automotive and Transportation conference.

• [By Sean Williams]

  For this week's round of "Better Know a Stock," I'm going to take a closer look at Heartland Express (NASDAQ: HTLD  ) .

  What Heartland Express does
  Heartland Express is a short-to-medium-haul truckload carrier of general commodities within the United States. It primarily is responsible for shipping automotive parts, retail goods, paper products, and packaged food.

Top 5 Freight Stocks To Buy Right Now: Canadian National Railway Co (CNR.TO)

Canadian National Railway Company (CN), incorporated on August 24, 1995, is engaged in the rail and related transportation business. CN�� network of approximately 20,100 route miles spans Canada and mid-America, connecting three coasts: the Atlantic, the Pacific and the Gulf of Mexico, serving the ports of Vancouver, Prince Rupert (British Columbia), Montreal, Halifax, New Orleans, and Mobile (Alabama) and metropolitan areas of Toronto, Buffalo, Chicago, Detroit, Duluth (Minnesota)/Superior (Wisconsin), Green Bay (Wisconsin), Minneapolis/St. Paul, Memphis and Jackson (Mississippi), with connections to all points in North America. CN�� network, and its co-production agreements, routing protocols, marketing alliances and interline agreements, provide CN customers access to all three North American Free Trade Agreement (NAFTA) nations. In March 2012, the Company acquired a locomotive program.

Petroleum and chemicals

The petroleum and chemicals commodity group consists of a range of commodities, including chemicals, sulfur, plastics, petroleum products and liquefied petroleum gas products. The Company�� petroleum and chemicals shipments originate in the Louisiana petrochemical corridor between New Orleans and Baton Rouge; in northern Alberta, and in eastern Canadian regional plants.

Metals and minerals

The metals and minerals commodity group consists primarily of non-ferrous base metals and ores, concentrates, iron ore, steel, construction materials, machinery and dimensional loads. The Company provides rail access to aluminum, mining, steel and iron ore producing regions.

Forest products

The forest products commodity group includes range of lumber, panels, paper, wood pulp and other fibers such as logs, recycled paper, wood chips, and wood pellets. The Company has rail access to the western and eastern Canadian fiber-producing regions. In United States, the Company is located to serve both the Midwest and southern United! States corridors with interline connections to other Class I railroads.

Coal

The coal commodity group consists of thermal grades of bituminous coal, metallurgical coal and petroleum coke. Canadian thermal and metallurgical coal is exported through terminals on the west coast of Canada to offshore markets. In United States, thermal coal is transported from mines served in southern Illinois, or from western United States mines through interchange with other railroads, to utilities in the Midwest and southeast United States, as well as offshore markets through terminals in the Gulf and the Port of Prince Rupert.

Grain and fertilizers

The grain and fertilizers commodity group depends primarily on crops grown and fertilizers processed in western Canada and the United States Midwest. The grain segment consists of three primary segments: food grains (mainly wheat, oats and malting barley), feed grains and feed grain products (including feed barley, feed wheat, peas, corn, ethanol and dried distillers grains), and oilseeds and oilseed nproducts (primarily canola seed, oil and meal, and soybeans).

Intermodal

The intermodal commodity group is consists of two segments: domestic and international. The domestic segment transports consumer products and manufactured goods, operating through both retail and wholesale channels, within domestic Canada, domestic United States., Mexico and transborder, while the international segment handles import and export container traffic, directly serving the ports of Vancouver, Prince Rupert, Montreal, Halifax and New Orleans.

Automotive

The automotive commodity group moves both finished vehicles and parts throughout North America, providing rail access to certain vehicle assembly plants in Canada, and Michigan and Mississippi in the United States. The Company also serves vehicle distribution facilities in Canada and the United States, as well as parts production facilities in Mi! chigan an! d Ontario. The Company serves shippers of import vehicles via the ports of Halifax and Vancouver, and through interchange with other railroads.

The Company competes with Canadian Pacific Railway Company.

Advisors' Opinion:

• [By Roadmap2Retire]

  I am also considering various stocks that are not currently in my portfolio, but the current high valuations do not provide many options.

  Canadian National Railway (CNR.TO) engages in transportation of goods including petroleum and chemicals, grain and fertilizers, coal, metals and minerals, forest products, intermodal, and automotive products. The company operates 20,100 route miles of track that spans Canada adn mid-America connecting the three coasts of Atlantic, Pacific and Gulf of Mexico. CNR is a dividend contender that has been raising its dividends for 17 consecutive years and has a 5-yr DGR of 13.9% and a 10-yr DGR of 17.4%. Norfolk Southern (NSC) engages in rail transportation of raw materials, intermediate and finished goods operating approximately 20,000 router miles across the southern and eastern US. NSC and other railroads stand to benefit from the oil boom in continental US, and before permanent pipelines are put in place, railroads are the only option available to transport the huge supplies. NSC is a dividend contender raising its dividends for 12 consecutive years and has a 5-yr DGR of 10.8% and 10-yr DGR of 21.1%. Procter & Gamble (PG) and Unilever plc (UL) are giants in the consumer packaged goods field. PG has five segments - beauty, grooming, healthcare, fabric care and home care. UL has four segments - personal care, foods, refreshment and home care. PG has been raising dividends for 57 years; has a 5-yr DGR of 10.2% and a 10-yr DGR of 10.8%. UL has been raising dividends for 25 years; has a 5-yr 7.07%. Aerospace & Defense Sector: With the global turmoils continuing and the rise of new conflicts across Eastern Europe and Middle East, I am considering adding some exposure to the Aerospace & Defense Sector. I recently posted an article regarding the current valuation of the stocks in the sector here. Index Funds - China ETF, Emerging Markets - I am considering adding a new index fund to my portfolio to track the Chinese marke

Top 5 Life Sciences Stocks To Watch Right Now

I'd hate to be short Pall (NYSE:PLL), as large companies in the filtration space often seem as close to bulletproof as you can find in the market. So even though sell-side analysts chronically overestimate Pall's free cash flow, investors remain happy with a company that admittedly enjoys strong share and a very lucrative channel of repeat business. While I think Pall's shares remain overvalued, I don't have any particular reason to believe that the shares will sell off dramatically, as the life sciences business should be stable and the industrial business should start improving next year.

On Target In Fiscal Q4
There are always plenty of moving parts within Pall's results, as the company sells into so many different end markets, but the end result performance was pretty much on target.

Revenue fell almost 1% as reported to close the fiscal year, but revenue in local currency terms rose half a point. Life sciences was up 6% for the quarter, as strength in biopharma offset weaker conditions in the Chinese and European food and beverage sector. Customer utilization levels in industrial markets remain a real issue, though, and the company saw a 5% decline (local currency) in industrial sales, with particular weakness in microelectronics and municipal water.

Best Wireless Telecom Companies To Watch For 2015: Tesco PLC (TSCDY)

Tesco PLC, incorporated on November 27, 1947, is engaged in retailing and associated activities in the United Kingdom, China, the Czech Republic, Hungary, the Republic of Ireland, India, Malaysia, Poland, Slovakia, South Korea, Thailand and Turkey. The Company also provides retail banking and insurance services through its subsidiary, Tesco Bank. The Company�� operations in the United Kingdom is the within the Company, with over 3,000 stores. The Company�� in-store picking model is complemented by a small number of specialized dotcom-only stores, which allow the Company to respond to customer demand. The Company�� Click & Collect service is a part of its multichannel offering and enables customers to pick up their shopping when and where it suits them. It has over 1,500 Click & Collect collection points for general merchandise and over 150 Grocery Drive-thrus in the United Kingdom.

The Company�� operations in India include sourcing and its service centre, as well as a franchise arrangement with Tata Group. The Company�� Hindustan Service Centre (HSC) is the global services arm for Tesco worldwide, providing business services for Tesco operations globally. Tesco HSC is engaged in creating and executing strategic initiatives covering information technology (IT), Financial, Commercial and Property, among others. The Company also provides 80% of the stock sold by Star Bazaar, both food and non-food, sourced through its distribution centre in Mumbai. This distribution centre also provides wholesale products to traditional Indian retailers, kirana stores, restaurants and other businesses, providing small farmers and other suppliers with a way to sell their wares to the local market.

The Company has an online business and 22 of virtual stores in South Korean subways and bus stops, which help time-pressed customers, shop on-the-go using their smartphones. Tesco Lotus is its international business, serving over 11 million customers every week in over 1,400 stores. Tesco Bank! offer a range of simple personal banking products, principally-mortgages, credit cards, personal loans, and savings.

Advisors' Opinion:

• [By Harvey Jones]

  LONDON -- You won't need telling that these are tough times for Tesco (LSE: TSCO  ) (NASDAQOTH: TSCDY  ) . The big cheese of British supermarkets has found itself in one pickle after another, serving up the U.S. Fresh & Easy debacle, its first profit warning for 20 years, a 25% share price drop, and a dollop of minced horsemeat. It has even been shrinking in Asia, with sales dropping 3.8% in the first quarter, on top of a 1% fall in U.K. sales. Chief executive Philip Clarke has given up the fight to sell electronics, abandoning the field to online giant Amazon.

Top 5 Life Sciences Stocks To Watch Right Now: Sbc Sveriges Bostadsrattscentrum AB (SBC)

SBC Sveriges BostadsrattsCentrum AB (SBC) is a Sweden-based company active within the real estate sector. It offers services to condominiums within three business areas, namely Financial Management, Technical Management and Legal Expertise. The Financial Management area offers services to real estate managers and residents, including services, such as accounting, payment management and budget optimization, among others. The Technical Management business area offers a range of services, including property inspection, documentation management and cost control, among others. Within the Legal Expertise area, the Company offers services, such as assistance in civil cases, assisting in negotiations, drafting of contracts and assistance in tax matters, among others. The Company has six offices located in the Swedish cities of Sundsvall, Uppsala, Vasteras, Stockholm, Malmo and Goteborg. As of December 31, 2011, it had two wholly owned subsidiaries, namely SBC Mark AB and Liljeholmsberget AB. Advisors' Opinion:

• [By Nitish]

  Stock-Based Compensation (SBC) ��In the second quarter of 2014, the total charge related to SBC was $880 million compared to $743 million in the second quarter of 2013. The analysts currently estimate SBC charges for grants made to employees prior to June 30, 2014 to be approximately $3.42 billion for 2014. This estimate does not include expenses to be recognized related to employee stock awards that are granted after June 30, 2014 or nonemployee stock awards that have been or may be granted.

Top 5 Life Sciences Stocks To Watch Right Now: Perfect World Co. Ltd.(PWRD)

Perfect World Co., Ltd., through its subsidiaries, engages in the research, development, operation, and licensing of online games primarily in the People?s Republic of China, the United States, and the Rest of Asia. It develops online games based on its game engines and game development platforms. The company?s 3D massively multiplayer online role playing games (MMORPGs) include Perfect World, an adventure and fantasy game with traditional Chinese settings; Legend of Martial Arts, an adventure story of Chinese swordsmen set in an ancient kingdom; and Perfect World II, which is set in a similar content and graphic background as Perfect World. It also offers Zhu Xian that is based on martial arts focused adventure set in a fantasy world; Chi Bi, a war story developed based on ancient Chinese history known as the Three Kingdoms; Hot Dance Party, a 3D online casual game; Pocketpet Journey West, a 3D MMORPG based on the classical novel of Chinese literature, Journey to the West ; Battle of the Immortals, a mysterious adventure, which enables game players to travel between eastern and western cultures, and adventures in historic sites and turf wars; and Fantasy Zhu Xian, a 2D turn-based MMORPG based on the Internet fantasy novel Zhu Xian. It also involves in the production and distribution of films, as well as television advertising activities. The company was founded in 2004 and is based in Beijing, the People?s Republic of China.

Advisors' Opinion:

• [By Sean Williams]

  What: Shares of Perfect World (NASDAQ: PWRD  ) , a China-based online video game developer, soared as much as 13% after the company reported better-than-expected first-quarter results.

• [By Paul Ausick]

  Before markets open Tuesday morning we are scheduled to hear results from Perfect World Co. Ltd. (NASDAQ: PWRD), Urban Outfitters Inc. (NASDAQ: URBN), Barnes & Noble Inc. (NYSE: BKS) which announced a new video app today, Best Buy Co. Inc (NYSE: BBY) which is included in our preview of this week�� results from retailers, Dick�� Sporting Goods Inc. (NYSE: DKS), Home Depot Inc. (NYSE: HD), J.C. Penney Co. Inc. (NYSE: JCP), and Trina Solar Ltd. (NYSE: TSL).

• [By Lauren Pollock]

  Perfect World Co.'s(PWRD) third-quarter profit rose 40% due largely to a revenue boost from the Chinese company’s core online-games business. American depositary shares of Perfect World were up 6% at $20 premarket as the company’s results for the period beat expectations.

• [By Kevin Chen]

  Two companies that seem on an unstoppable path of profits are Giant Interactive� (NYSE: GA  ) and NetEase (NASDAQ: NTES  ) .�Meanwhile, Shanda Games� (NASDAQ: GAME  ) and Perfect World� (NASDAQ: PWRD  ) haven't done as well.

Top 5 Life Sciences Stocks To Watch Right Now: Krispy Kreme Doughnuts Inc (KKD)

Krispy Kreme Doughnuts, Inc. (Krispy Kreme), December 02, 1999, is a retailer and wholesaler of doughnuts complementary beverages and treats and packaged sweets. The Company�� principal business is owning and franchising Krispy Kreme stores, at which a variety of doughnuts, including the Company�� Original Glazed doughnut, are sold and distributed together with complementary products, and where a broad array of coffees and other beverages are offered. As of February 3, 2013, there were 239 Krispy Kreme stores operated domestically in 38 states and in the District of Columbia, and there were 509 shops in 21 other countries around the world. Of the 748 total stores, 295 were factory stores and 453 were satellites. The Company operates in four segments: Company Stores, domestic franchise stores, international franchise stores, and the KK Supply Chain.

Company Stores

Its Company Stores segment consists of the operating activities of its Company-owned stores. These stores sell doughnuts and complementary products through the on-premises and wholesale channels. Many of the doughnut varieties the Company offers in its doughnut shops also are distributed, through off-premises sales channels. In addition, it offers a number of products through off-premises channels, including honeybuns, fruit pies, mini-crullers, cupcakes and various chocolate enrobed products, generally packaged as individually wrapped snacks or packaged in snack bags. Krispy Kreme has a beverage program, which includes drip coffees, both coffee-based and noncoffee-based frozen drinks, juices, sodas, milks, water and packaged and fountain beverages. In addition, the Company also develops beverages such as espresso, cappuccino and hot chocolate.

Domestic Franchise

The Domestic Franchise segment consists of the Company�� domestic store franchise operations. This segment derives revenue principally from initial development and franchise fees related to new stores and from royalties on sa! les by franchise stores. As of February 3, 2013, there were 142 domestic franchise stores in 29 states, consisting of 99 factory and 43 satellite stores.

International Franchise

The International Franchise segment consists of the Company�� international store franchise operations. International franchise stores sell doughnuts and complementary products almost exclusively through the on-premises sales channel using shop formats similar to those used in the United States, and also using a kiosk format. A portion of sales by the franchisees in Canada, the United Kingdom and Australia are made to wholesale customers. As of February 3, 2013, there were 509 international franchise shops in 21 countries, consisting of 120 factory stores and 389 satellite shops.

KK Supply Chain Business Segment

The Company operates an integrated supply chain. The KK Supply Chain segment buys and processes ingredients it uses to produce doughnut mixes and manufactures doughnut-making equipment that all factory stores are required to purchase. The Company manufactures doughnut mixes at its facility in Winston-Salem, North Carolina. In addition to traditional doughnut mixes and mixes made from mix concentrate, the Company produces or manages the production of doughnut premix, which is used to produce doughnut mixes in certain international locations. The KK Supply Chain segment also purchases and sells supplies, including icings and fillings, other food ingredients, juices, signage, display cases, uniforms and other items to both Company and franchisee-owned stores.

The Company competes with Dolly Madison, Entenmann��, Hostess, Little Debbie, and Sara Lee.

Advisors' Opinion:

• [By Myra P. Saefong]

  Krispy Kreme Doughnuts shares (KKD) �were up 9.4% in the after-hours trading session.

• [By Ben Levisohn]

  Shares of Krispy Kreme Doughnuts (KKD) have tumbled in after-hours trading after the purveyor of doughnuts met earnings forecasts but lowered guidance.

  Krispy Kreme’s first-quarter results weren’t all that bad. It reported a first-quarter profit of 23 cents a share, in line with analyst forecasts for 23 cents, on revenue of 121.6 million, beating estimates for $125.53 million. It’s guidance, however, went over about as well as a mud-flavored doughnut, as Krispy Kreme lowered its full-year earnings forecast to a range of 69 cents to 74 cents, below its previous range of 73 cents to 79 cents. Ouch.

  Shares of Krispy Kreme have dropped 9.7% to $17.16 at 4:20 p.m. in after-hours trading today. Krispy Kreme gained 0.9% to $19 in regular hours, lagging Dunkin Brands (DNKN) 2.7% rise to $45.97.

• [By Laura Brodbeck]

  Monday

  Earnings Releases Expected: FedEx Corporation (NYSE: FDX), Goldmans Stores, Inc. (NASDAQ: GMAN), Thor Industries, Inc. (NYSE, THO), Krispy Kreme Doughnuts, Inc. (NYSE: KKD), Shoe Carnival, Inc. (NASDAQ: SCVL) Economic Releases Expected: Spanish manufacturing PMI, French manufacturing PMI, German manufacturing PMI, eurozone manufacturing PMI, British manufacturing PMI, US ISM manufacturing PMI, Reserve Bank of Australia interest rate decision.

  Tuesday

• [By Alexis Xydias]

  Krispy Kreme Doughnuts Inc. (KKD) plunged 14 percent in early U.S. trading after quarterly revenue missed estimates. Yum (YUM)! Brands Inc., the owner of KFC and Pizza Hut, fell 2.8 percent in Germany after releasing a financial update that showed volatile Chinese sales. Apple Inc. (AAPL) rose 0.9 percent in New York after UBS AG advised buying the shares.

Top 10 Canadian Stocks To Invest In 2014

If you're just out of college and uncertain what to do ��or even if you're well into your twenties and not sure about where to go next ��you may be dreaming about living abroad. Now is the time to do it, before you're tied down with a career, family or mortgage. With the right visa, you might be able to live abroad for up to a year, work any job you like, and use your earnings to travel in between assignments.

See Also: Secrets to Save on Travel

When I left my home in Toronto after university for a year in New Zealand, I signed up with a Canadian program called SWAP that facilitates working holiday visas for 18- to 30-year-olds (and sometimes older participants). It included an orientation session with SWAP's partner organization in New Zealand and access to a 24-hour emergency line should any problems arise throughout my trip. Other programs, such as the U.S.-based BUNAC, also offer help with applying for a visa and preparing for the trip, as well as on-the-ground support and perks after you arrive.

Top Specialty Retail Companies To Watch For 2015: Iamgold Corporation(IAG)

IAMGOLD Corporation, together with its subsidiaries, engages in the exploration, development, and production of mineral resource properties worldwide. It primarily explores for gold, silver, zinc, copper, niobium, diamonds, and other metals. The company holds interests in eight operating gold mines, a niobium producer, a diamond royalty, and exploration and development projects located in Africa and the Americas. Its advanced exploration and development projects include the Westwood project in Canada; and the Quimsacocha project, which consists of 3 mining concessions covering an aggregate area of approximately 8,030 hectares in Ecuador. The company was formerly known as IAMGOLD International African Mining Gold Corporation and changed its name to IAMGOLD Corporation in June 1997. IAMGOLD Corporation was founded in 1990 and is based in Toronto, Canada.

Advisors' Opinion:

• [By Patricio Kehoe]

  In addition to overexpansion at the wrong time, Golden Star�� position has weakened due to its comparably less efficient operations. Unlike industry peers, such as IamGold Corp. (IAG) or Gold Fields Ltd. (GFI), the majority of the Toronto-based miner�� assets contain refractory ore, which is far more expensive to extract than non refractory ore. And, in an attempt to switch production to the lower cost gold ore, and thus increase margins, Golden Star has depleted its mines��non refractory ore. With low reserves and mounting cash costs, the firm inevitably turned to new acquisitions.

• [By Eric Volkman]

  IAMGOLD (NYSE: IAG  ) might specialize in a precious metal, but it's continuing to pay its dividend in hard currency. The company has declared its latest semi-annual distribution at $0.125 per share of its common stock.

• [By Namitha Jagadeesh]

  International Consolidated Airlines Group SA (IAG) and Air France-KLM (AF) Group rose with as a gauge of travel stocks as oil prices fell after Iran�� accord. PSA Peugeot Citroen gained 3.7 percent after people familiar with the matter said its chief executive officer plans to step down next year. Fresenius Medical Care AG surged the most in five years after U.S. regulators scrapped a plan to cut Medicare payments next year.

Top 10 Canadian Stocks To Invest In 2014: Crown Castle International Corporation (CCI)

Crown Castle International Corp., through its subsidiaries, owns, operates, and leases towers and other wireless infrastructure primarily in the United States and Australia. Its infrastructure includes distributed antenna system (DAS) networks, as well as rooftop installations. The company involves in the rental of antenna space of its towers to wireless communications companies. It also provides network services relating to its towers, which primarily include antenna installations and subsequent augmentations, as well as additional services, such as site acquisition, architectural and engineering, zoning and permitting, other construction, and other services related network development. As of December 31, 2010, it owned, leased, or managed approximately 23,900 towers, including 43 completed DAS networks. The company was founded in 1994 and is headquartered in Houston, Texas.

Advisors' Opinion:

• [By Steve Sears]

  New stocks in what Goldman calls the “Hedge Fund VIP list,”�include Actavis (ACT), Baidu (BIDU), Berkshire Hathaway (BRK.B), Crown Castle International (CCI), Entergy Louisiana (ELB), �Equinix (EQIX), Facebook (FB), Fleetcor Technologies (FLT), W.R. Grace (GRA), MetLife (MET), Macquarie Infrastructure (MIC), Micron (MU), Time Warner Cable (TWC), and Time Warner (TWX).

• [By Victor Selva] the benefits of being in the right place at the right time.

  As a matter of fact, the company is the second largest independent operator of wireless tower communication sites in the U.S. and it is the leading tower owner, with roughly 40,000 sites domestically and over 1,700 in Australia.

  The firm leases and licenses antenna spaces on its controlled towers to major wireless carriers such as AT&T Inc. (T), Sprint Nextel Corporation (S) and Verizon Communications Inc. (VZ). Moreover, it leases access to its distributed antenna systems for the transmission of wireless signals related to the transmission of voice, video and data.

  Long Lasting Upsides with Low Risk

  Crown Castle has many advantages running to its favor, which have carved the company a narrow economic moat. For one, it boasts great visibility stemming from the fact that its long term contracts have enabled the firm to have more than 97% of its coming year�� revenue projections already assured.

  Secondly, high switching costs make it unlikely for carriers to switch towers, since the costs of such a move would by far exceed the savings from changing to another operator. In addition, zoning regulations hinder carriers to do so. Third, its economies of scale allow the company great cost advantages that result in massive operating leverage.

  And lastly, there is the upside of the network effect. Since each tower covers a specific area, multiple carriers will be willing to have presence in the same towers, given this is directly connected to their ability to compete over market share in the areas covered by each site.

  Creating Shareholder Value

  In early January 2014, Crown Castle began operating as a real estate investment trust. Upon the announcement of this decision, chief executive Ben Moreland stated that this conversion should ��ower our weighed average cost of capital and provide additional opportunities for creating long-term shareholder value.��I

• [By Alexis Xydias]

  Crown Castle International Corp. (CCI) climbed 2.7 percent to $72.45. The provider of infrastructure for wireless communications said it will take steps to qualify as a real estate investment trust for tax purposes.

• [By Jon C. Ogg]

  We just gave a fresh synopsis of which telecom and wireless players could still be up for M&A in the final round of consolidation. American Tower’s market cap is about $28 billion and shares are up more than 4.5% at $71.75. To show how hard things have been, the 52-week trading range is $67.89 to $85.26. What today’s transaction does is quite simply add value to the rest of the public companies that own and operate cell towers:

  Crown Castle International Corp. (NYSE: CCI) is up almost 2.5% at $70.90, against a 52-week range of $63.16 to $81.16. SBA Communications Corp. (NASDAQ: SBAC) is up about 1.8% at $76.70. against a 52-week range of $59.00 to $82.31.

  American Tower expects that the portfolio addition will generate about $345 million in revenues and approximately $270 million of gross margin in 2014. If you value the deal solely on the 5,400 or so owned U.S. towers, this comes up to about $611,000 per tower before calculating the debt and other rights. Suddenly, SBA Communications Corp. (NASDAQ: SBAC) is vindicated because a deal it made in 2012 was deemed pricey as it paid about $1.45 billion for 3,252 towers from TowerCo, at about $445,000 per tower. Crown Castle also has spent close to $2.4 billion to acquire T-Mobile cell tower rights in late 2012.

Top 10 Canadian Stocks To Invest In 2014: Progressive Waste Solutions Ltd. (BIN)

Progressive Waste Solutions Ltd. operates as a vertically integrated non-hazardous solid waste management company in North America. It operates through three segments: Canada, the U.S. south, and the U.S. northeast. The company provides waste collection, transfer, recycling, and disposal services to commercial, industrial, municipal, and residential customers in 13 U.S. states, the District of Columbia, and 6 Canadian provinces. It also owns and operates a power generating plant fuelled by landfill gas; and generates and sells methane gas. The company was formerly known as IESI-BFC Ltd. and changed its name to Progressive Waste Solutions Ltd. in May 2011. Progressive Waste Solutions Ltd. was founded in 2001 and is based in Vaughan, Canada.

Advisors' Opinion:

• [By Sean Williams]

  Keep in mind, though, this is a sectorwide problem, not just one affecting Waste Management. Canada's Progressive Waste Solutions (NYSE: BIN  ) delivered an 11% increase in first-quarter revenue but succumbed to a decrease of 0.5% in recycling revenue because of lower realized metal prices. �

Top 10 Canadian Stocks To Invest In 2014: Silver Wheaton Corp(SLW)

Silver Wheaton Corp., together with its subsidiaries, operates as a silver streaming company worldwide. The company has 14 long-term silver purchase agreements and 2 long-term precious metal purchase agreements whereby it acquires silver and gold production from the counterparties located in Mexico, the United States, Canada, Greece, Sweden, Peru, Chile, Argentina, and Portugal. Silver Wheaton Corp. is headquartered in Vancouver, Canada.

Advisors' Opinion:

• [By Itinerant]

  Barrick Gold also has obligations to pay Royal Gold (RGLD) a royalty on some of the precious metal output from the mine once operational; and more importantly, the company has given a completion guarantee to Silver Wheaton (SLW) as part of a deal that saw Silver Wheaton contribute $625M towards capex in 2009 in exchange to buy 25% of the produced silver for a discounted price of $3.90. If the mine is not completed by December 31, 2015, then Silver Wheaton has the right to ask for its money back. Silver Wheaton will be thinking of ways to manage its share of the disaster as confirmation has now been given that Pascua-Lama will not be completed by that dead line. For the moment, Silver Wheaton has extended the deadline by one year to December 31, 2016, and has reduced the guidance for 2017.

• [By Dan Caplinger]

  Motley Fool contributing writer Dan Caplinger explains silver streaming, the unique�business model of Silver Wheaton (NYSE: SLW  ) , whereby SLW offers financing to mining companies in return for the right to buy future production of silver at a discount.

• [By Doug Ehrman]

  Despite the weakness seen in precious metals a few weeks ago, silver has been relatively stable ever since mid-April, with the iShares Silver Trust (NYSEMKT: SLV  ) trading in a dollar-wide range ever since. With the presidents of the Chicago and Philadelphia Federal Reserve banks��releasing conflicting statements, turmoil may be just around the corner. Miners like Pan American (NASDAQ: PAAS  ) and First Majestic (NYSE: AG  ) are still facing operating challenges, while silver streaming darling Silver Wheaton (NYSE: SLW  ) struggles as well.

Top 10 Canadian Stocks To Invest In 2014: Concord Medical Services Holdings Limited (CCM)

Concord Medical Services Holdings Limited, together with its subsidiaries, operates a network of radiotherapy and diagnostic imaging centers in the People�s Republic of China. The company�s services comprise linear accelerators external beam radiotherapy, gamma knife radiosurgery, head gamma knife systems, body gamma knife systems, proton beam therapy, diagnostic imaging, and other treatment and diagnostic modalities. It offers clinical support services; develops treatment protocols for doctors; and organizes joint diagnosis between doctors in its network and clinical research. The company also operates a specialty cancer hospital, as well as leases medical and diagnostic equipment. As of March 31, 2011, it operated a network of 121 centers with 68 hospital partners that cover 46 cities and 24 provinces, and administrative regions in China. The company was founded in 1996 and is headquartered in Beijing, the People�s Republic of China.

Advisors' Opinion:

• [By John Udovich]

  China is set to ease the one child policy, something that could benefit Chinese stocks in general but be especially beneficial to insurance stocks like China Life Insurance Company Ltd (NYSE: LFC) and CNinsure Inc (NASDAQ: CISG) plus health care stocks like Mindray Medical International Ltd�(NYSE: MR) and Concord Medical Services Hldg Ltd (NYSE: CCM). First, let�� be clear that China is NOT abolishing the one child policy as the changes will merely�allow married couples to have two children if one spouse is an only child plus it will be up to China�� 34 province-level administrations to revise�their laws and put the new policy into effect. Moreover, China�� family-planning bureaucracy employs more than 500,000 full-time workers and six million part-time workers all the way down to the village level to�collect billions of dollars in fines and these bureaucrats have fought for years against policy changes���meaning they could throw up roadblocks if not placated. With that said, the insurance and health care sectors are two sectors with publicly Chinese stocks that look set to�take advantage of the coming changes.

Top 10 Canadian Stocks To Invest In 2014: Agnico-Eagle Mines Limited(AEM)

Agnico-Eagle Mines Limited, through its subsidiaries, engages in the exploration, development, and production of mineral properties in Canada, Finland, and Mexico. The company primarily explores for gold, as well as silver, copper, zinc, and lead. Its flagship property includes the LaRonde mine located in the southern portion of the Abitibi volcanic belt, Canada. The company was founded in 1953 and is based in Toronto, Canada.

Advisors' Opinion:

• [By Louis Navellier]

  Agnico-Eagle Mines (AEM) runs mineral properties in Canada, Finland and Mexico. Gold is AEM�� primary focus but it also looks for and mines silver, copper, zinc and lead.

• [By Daniel Putnam]

  The second factor working in gold stocks��favor is that analysts are growing optimistic again. Yesterday, HSBC put out a bullish note on gold and upgraded Agnico Eagle Mines (AEM), Yamana Gold (AUY), Barrick Gold, Iamgold (IAG), and Goldcorp. Most gold stocks are ranked ��old��or ��uy��(as opposed to ��trong Buy�� by the majority of analysts, meaning that there�� plenty of room for continued positive news flow on this front.

Top 10 Canadian Stocks To Invest In 2014: TotalFinaElf S.A.(TOT)

TOTAL S.A., together with its subsidiaries, operates as an integrated oil and gas company worldwide. The company operates through three segments: Upstream, Downstream, and Chemicals. The Upstream segment engages in the exploration, development, and production of oil and natural gas. It also involves in the transportation, trade, and marketing of natural gas and liquefied natural gas (LNG), as well as in LNG re-gasification and natural gas storage operations. In addition, this segment engages in the shipping and trade of liquefied petroleum gas (LPG); power generation from gas-fired power plants, nuclear, or renewable energies; production, trade, and marketing of coal, as well as in solar power systems and technology operations. As of December 31, 2010, it had combined proved reserves of 10,695 Mboe of oil and gas. The Downstream segment involves in refining, marketing, trading, and shipping crude oil and petroleum products. It also produces a range of specialty products, s uch as lubricants, LPG, jet fuel, special fluids, bitumen, marine fuels, and petrochemical feedstock. This segment holds interests in 24 refineries located in Europe, the United States, the French West Indies, Africa, and China, as well as operates a network of 17,490 service stations. The Chemicals segment produces base chemicals, including petrochemicals and fertilizers, as well as engages in rubber processing, resins, adhesives, and electroplating activities. TOTAL S.A. was founded in 1924 and is based in Paris, France.

Advisors' Opinion:

• [By Jayson Derrick]

  Total (NYSE: TOT) announced that its European refining margin fell to $6.60 per metric ton in the first quarter from $26.90 per metric ton in the same quarter last year. Shares gained 0.09 percent, closing at $67.79.

• [By Aaron Levitt]

  But BP wasn�� done yet. The second major deal for BP was a huge $45 billion project with partners such as Norway�� Statoil (STO) and France’s Total (TOT). This project will tap the plethora of natural gas trapped under Azerbaijan�� massive Shah Deniz field, then pipe that bounty all the way into Italy and Europe. Bringing gas from Azerbaijan to Europe is being seen a strategic move that will lessen the reliance on Russian exports and Gazprom�� (OGZPY) current monopoly.

5 Best Safest Stocks To Watch Right Now

Today, I put in a buy order for the Ben Graham: Net-Net Newsletter�� 14th position. What makes this stock so different from past picks?

In the past, the Ben Graham: Net-Net Newsletter has never bought a stock that doesn�� file with the SEC. This month ��if we get our order filled ��the model portfolio will finally own a net-net that doesn�� file with the SEC.

Some net-nets don�� file with the SEC. But a lot of net-nets do. And if the idea was just to assemble a random collection of net-nets ��we wouldn�� need to lift this restriction.

But my idea for the Ben Graham: Net-Net Newsletter has been to try to find the single best, single safest net-net each month. And buy that stock using a real brokerage account.

What makes a net-net the ��ingle best, single safest��net-net?

There are a lot of ways to measure this. But probably the simplest way to separate safe net-nets from unsafe net-nets is the number of consecutive years of profits. A net-net that has been profitable in 15 of the last 15 years is usually a better net-net to buy than one that lost money last year.

Best Financial Stocks For 2015: Fibria Celulose SA (FIBR3)

Fibria Celulose SA, formerly Votorantim Celulose e Papel SA, is a Brazil-based company involved in the production and sale of short fiber pulp. The Company operates pulp manufacturing plants in Aracruz (Espirito Santo), Tres Lagoas (Mato Grosso do Sul), Jacarei (Sao Paulo) and Veracel (Bahia). Additionally, the Company is engaged in the cultivation of eucalyptus. It has plantations in the Brazilian states of Sao Paulo, Minas Gerais, Rio de Janeiro, Mato Grosso do Sul, Bahia and Espirito Santo. In 2011, the Company sold a business unit active in paper production. The Company has a number of subsidiaries in Brazil and abroad, including Normus Empreendimentos e Participacoes Ltda, Fibria Overseas Finance Ltd and Fibria Celulose (USA) Inc, among others. On October, 2013, the Company announced merger by incorporation of Normus Empreendimentos e Participacoes Ltda, a wholly-owned subsidiary of the Company, in order to simplify the corporate structure. Advisors' Opinion:

• [By Harry Suhartono]

  The Ibovespa dropped 1.8 percent as iron-ore producer Vale SA (VALE5), whose main export market is China, snapped a two-day gain. Pulp producer Fibria Celulose SA (FIBR3) retreated after posting quarterly earnings that trailed analysts��estimates. Brazil plans to sell dollar bonds due in 2025, creating a new benchmark security in international markets, and buy back notes maturing in as little as four years.

• [By Julia Leite]

  Fibria Celulose SA (FIBR3), the world�� largest pulp producer, climbed after settling a tax dispute with Brazil over profits at its foreign units. Iron-ore producer Vale SA (VALE5) gained before a report due this weekend forecast to show manufacturing is still expanding in China, the company�� main export market.

5 Best Safest Stocks To Watch Right Now: EMCOR Group Inc. (EME)

EMCOR Group, Inc. provides electrical and mechanical construction, and facilities services primarily to commercial, industrial, utility, and institutional customers in the United States, the United Kingdom, and internationally. The company offers various electrical and mechanical systems, including electric power transmission and distribution systems, such as power cables, conduits, distribution panels, transformers, generators, uninterruptible power supply systems, and related switch gear and controls; premises electrical and lighting systems, including fixtures and controls; low-voltage systems comprising fire alarms, and security and process control systems; voice and data communications systems, including fiber-optic and low-voltage cabling systems; and roadway and transit lighting and fiber-optic lines. It also provides heating, ventilation, air conditioning, refrigeration, and clean-room process ventilation systems; fire protection systems; plumbing, processing, and piping systems; controls and filtration systems; water and wastewater treatment systems; central plant heating and cooling systems; cranes and rigging; millwrighting; and steel fabrication, erection, and welding systems. In addition, the company offers facilities services comprising industrial maintenance and services; outage services to utilities and industrial plants; commercial and government site-based operations and maintenance; military base operations support; mobile mechanical maintenance and services; floor care and janitorial; landscaping, lot sweeping, and snow removal; facilities and vendor management; call center; building systems installation and support; and technical consulting and diagnostic services. Further, it provides small modification and retrofit projects; retrofit projects; and program development, management, and maintenance services for energy systems. EMCOR Group, Inc. was founded in 1966 and is headquartered in Norwalk, Connecticut.

Advisors' Opinion:

• [By Seth Jayson]

  When judging a company's prospects, how quickly it turns cash outflows into cash inflows can be just as important as how much profit it's booking in the accounting fantasy world we call "earnings." This is one of the first metrics I check when I'm hunting for the market's best stocks. Today, we'll see how it applies to EMCOR Group (NYSE: EME  ) .

• [By Eric Volkman]

  EMCOR Group (NYSE: EME  ) is growing the old-fashioned way -- with the purchase of outside assets. The company announced�that it will acquire the privately held RepconStrickland, a Texas-based firm it describes as "a leading provider of recurring turnaround and specialty services to the North American refinery and petrochemical markets."

5 Best Safest Stocks To Watch Right Now: Gotesco Land Inc (GO)

Gotesco Land, Inc. (GLI) is the holding company of Ever-Gotesco Group of Companies for its property development projects. The Company is primarily engaged in acquiring, developing, administering, selling, managing or otherwise dealing in real estate transactions. The Company, together with its subsidiaries, operates in two business segments. The real estate segment is engaged in the development and sale of real properties. The leasing segment is egnaged in the leasing of clubhouse and resort facilities. As of December 31, 2011, the Company's wholly owned subsidiaires included Chateau Royale Sports & Country Club, Inc. (CRSCCI), Evercrest Cebu Golf Club & Resort, Inc. (ECGCRI), Gulod Resort, Inc. (GRI), Multiresources Holding Company, Inc. (MHCI) and Nasugbu Resort, Inc. (NRI). Advisors' Opinion:

• [By Emerging Opportunities]

  Gross output (GO) measures the total output of an economy, including investments made by businesses in order to produce their goods, such as capital outlays on new equipment, raw materials, or other business-to-business transactions. In Structure, Skousen makes the case that modern economists downplay the importance of the business sector in the economy and overstate the importance of consumer spending. He believes that the GDP should not be used as the sole measure of economic activity.

• [By Mark Salzinger, Editor and Publisher, No-Load Fund Investor]

  The former are called General Obligation (GO) bonds, while the latter are generally called revenue bonds. In the old days, GOs were considered safer, because they were backed by the full taxing authority of the issuer. Now, revenue bonds are more in vogue.

5 Best Safest Stocks To Watch Right Now: Polypore International Inc(PPO)

Polypore International, Inc., a technology filtration company, develops, manufactures, and markets specialized microporous membranes used in separation and filtration processes. It operates in two segments, Energy Storage and Separations Media. The Energy Storage segment offers membranes that provide the function of separating the cathode and anode in applications, including lithium-ion batteries that are used in portable electronic devices, energy storage systems, cordless power tools, and electric drive vehicles; and lead-acid batteries used in automobiles, other motor vehicles, forklifts, and uninterruptible power supply systems. The Separations Media segment provides membranes that are used as high technology filtration element in various medical and industrial applications. This segment?s membranes and membrane modules are used in applications, such as hemodialysis, blood oxygenation, plasmapheresis and various high-performance microfiltration, ultrafiltration, and g asification/degasification applications. Polypore International, Inc. sells its products to manufacturers and converters who incorporate its products into their finished goods. The company sells its products and services in North America, South America, Europe, and Asia through its direct sales force, and distributors and agents. The company is headquartered in Charlotte, North Carolina.

Advisors' Opinion:

• [By John Udovich]

  When most people think of electric vehicle stocks, they probably think of troubled Tesla Motors Inc (NASDAQ: TSLA) or one of the several Chinese stocks active in the space, but North America based large cap Magna International Inc (NYSE: MGA) and small caps Polypore International, Inc (NYSE: PPO), UQM Technologies Inc (NYSEMKT: UQM) and Green Automotive Company (OTCMKTS: GACR) are all players, one way or the other, in the electric vehicle space that most investors have probably overlooked or just aren�� aware of. Of course, we can argue�about whether or not purely electric vehicles or some sort of hybrid vehicles are the way of the future, but what cannot be argued about is the fact that the following electric vehicle stocks are at the forefront of EV or�hybrid technology and design:

Top 5 Healthcare Technology Companies To Buy For 2015

Top 5 Healthcare Technology Companies To Buy For 2015: Allison Transmission Holdings Inc (ALSN)

Allison Transmission Holdings, Inc. (Allison), incorporated on June 22, 2007, designs and manufactures commercial and military fully-automatic transmissions. The Company is a manufacturer of fully-automatic transmissions for medium- and heavy-duty commercial vehicles, medium- and heavy-tactical the United States military vehicles and hybrid-propulsion systems for transit buses. Allison transmissions are used in a range of applications, including on-highway trucks (distribution, refuse, construction, fire and emergency), buses (primarily school and transit), motorhomes, off-highway vehicles and equipment (energy and mining) and military vehicles (wheeled and tracked). In January 2014, the Company opened a facility in the Netherlands to serve customers across Europe, the Middle East and Africa.

Allison transmissions are sold under the Allison Transmission brand name and remanufactured transmissions are sold under the ReTran brand name. The Company has 12 transmi ssion product lines with over 100 different product models. Allison transmissions are included in more than 2,500 vehicle configurations, which are compatible with more than 500 combinations of engine brands, models and ratings globally. In addition to the Company's product offerings, the Company has products under development, including the TC10, a Class 8 metro truck fully-automatic transmission, and the H 3000 and the H 4000 hybrid-propulsion systems designed for use in medium- and heavy-duty commercial trucks and buses.

North America

The Company is a manufacturer of fully-automatic transmissions for the on-highway medium- and heavy-duty commercial vehicle markets in North America. The Company's core North American on-highway market includes Class 4-5, Class 6-7 and Class 8 straight trucks, conventional transit, shuttle and coach buses, school buses and motorhomes. Class 8 trucks are subdivided into! two markets: straight and tractor. The Company sells its transmissions in the North American on-highway mar! ket to original equipment manufacturers (OEMs), including Blue Bird, Daimler, Hino, Navistar, PACCAR, Spartan Motors and Volvo. These OEMs, in turn, install the Company's transmissions in vehicles in which its transmission is either the exclusive transmission available or is specifically requested by end users who are choosing between a manual transmission, an AMT or a fully-automatic transmission. The Company's vehicle class in North America include Class 4-5 Trucks, Class 6-7 Trucks, Class 8 Straight Trucks, Buses and

Motorhomes

Class 4-5 trucks are used in urban applications, including distribution, commercial lease and rental, as well as ambulance. The Company is the transmission supplier to the Navistar Class 4-5 TerraStar truck. Class 6-7 trucks are used in urban applications, including larger distribution, commercial lease and rental, ambulance, rescue and fire trucks. The Company's transmissions are used in Class 6-7 buses. The Company supp lies its transmissions for all of the school buses produced in North America. The bus market also encompasses non-hybrid transit and conventional coach and shuttle buses. The Company sells its transmissions for use in larger motorhomes ( types A). The Company typically sells to the chassis manufacturers, such as Navistar and Daimler, that supply body manufacturers, such as Thor Industries, Winnebago Industries and Fleetwood RV. As of December 31, 2012, the Company has delivered over 5,000 H 40/50 EP hybrid-propulsion transit bus systems globally to 246 cities in 14 countries. The Company's customers in this North American end market are typically city, state and federal governmental entities. The Company has provided products used in vehicles and equipment, which serve energy, mining and construction applications. Its customers include Halliburton Company, Baker Hughes, Weatherford International, National Oilwell Varco, ! and Key E! nergy Services. The Company also provides heav y-duty transmissions used in mining trucks, specialty and co! nstructio! n vehicles. Mining applications include trucks used to haul various commodities and other products, including rigid dump trucks, underground trucks and long-haul tractor trailer trucks with load capacities between 40 to 110 tons. Specialty vehicles using the Company's heavy-duty transmissions include airport rescue and firefighting vehicles and heavy-equipment transporters.

Outside North America

The Company is a manufacturer of fully-automatic transmissions for the commercial vehicle markets outside of North America. Within Europe, the Company serves Western European developed markets, as well as Russian and Eastern European emerging markets. The Company's on-highway customers in these markets are Daimler, Iveco, Scania, and Volvo. Fully-automatic transmission technology has approximately a 6% market share in European truck applications. The Company supplies transmissions to European OEMs. The Company is the exclusive transmission in refuse chassis with Daimler, Dennis Eagle and Renault SA. The Company also supply mining OEMs, such as Atlas Copco UK, Perlini Equipment, Sandvik AB and Terex. As of December 31, 2012, in China, the Company is the provider of fully-automatic commercial vehicle transmissions with a substantial installed base of over 45,000 Allison transmissions, including 30,000 units in transit buses, operated by 90 different bus fleets in 55 cities. The Company's off-highway transmissions are also used in China for energy, mining and construction, by OEM customers including 4th Petroleum and Yantai Jereh Oilfield Services Group Co. in energy applications and Qinhuangdao Tolian Speciality Transporter Co., Sany Group Co. and North Hauler in mining and construction applications. Australia and South Korea have OEMs with domestic production capabilities for which the Company is a supplier, including Iveco, Hyundai Motor Company and Daewoo Intern! ational C! orporation.

Military

The Comp any sells all of the transmissions for medium- and heavy-tac! tical whe! eled vehicle platforms, including the Family of Medium Tactical Vehicles, Armored Security Vehicles, Heavy Expanded Mobility Tactical Trucks, Heavy Equipment Transporters, Palletized Loading Systems, M915 Series Trucks, Medium Tactical Vehicle Replacements and the Logistic Vehicle System Replacement. In addition, the Company supplied transmissions for Mine-Resistant Ambush Protected (MRAP) Vehicles and the MRAP All Terrain Vehicle and for all three potential manufacturers of the Joint Light Tactical Vehicles. Transmissions for the Company's wheeled vehicle platforms are sold to OEMs, including BAE, Daimler, General Dynamics Land Systems, Oshkosh, Navistar and Textron Marine & Land Systems.

The Company is the supplier on two of the three key tracked vehicle platforms, the Abrams tank and the M113 family of vehicles, which are sold directly to the United States military. Additionally, the Company sells parts kits to licensees for the production of transmissions fo r tracked vehicles manufactured outside North America. The Company has been selected as the transmission supplier for the prime contractors bidding for the United States Army ground combat vehicle.

Service Parts, Support, Equipment and Other (Aftermarket)

Aftermarket provides the Company with a source of revenues as the installed base of vehicles and equipment utilizing the Company's transmissions. The Company has assembled a global network of approximately 1,400 distributor and dealer locations to sells, service and support its transmissions. As part of the Company's brand strategy, its independent distributors and dealers are required to sell genuine Allison-branded parts. The Company offers remanufactured transmissions under its ReTran brand. The Company also provides support equipment to its OEMs to assist in installing new Allison transmissions into vehicles.

!

The Co! mpany competes with Ford Motor Company, Eaton Corp., Voith GmbH, Z F Friedrichshafen AG, BAE, Caterpillar Inc., Twin Disc, Inco! rporated,! Komatsu, Ltd., Aisin Seiki Co., Ltd., JATCO Ltd, Mitsubishi Fuso Truck and Bus Corporation, Hino, Isuzu and Nissan Diesel, Danyang Winstar Auto Parts Co., Ltd., Tata, Ashok Leyland, JCBL Ltd., Asia Motor Works Limited, BEML, Renk AG and L-3 Communications Corporation.

Advisors' Opinion:

• [By Rich Duprey]

  Approving an increase in the quarterly cash dividend paid to shareholders, transmission manufacturer Allison Transmissions (NYSE: ALSN  ) announced today that its board of directors doubled the payout from$0.06per share to$0.12per share while also providing preliminary estimates for its first quarter, which ended March 31.

• [By Ben Levisohn]

  2Q14 Machinery results are likely to reflect what we view as a still mixed but improving macroeconomic environment that we think could support pockets of strength in Machinery end markets. In particular, we think both North American truck and North American energy markets continue to improve while global construction markets look supportive of continued solid/better-than-expected results (mostly from improved margin) in Caterpillar’s Construction segment. Solid truck, energy and construction markets seem supportive of earnings for Caterpillar as well as truck suppliers Cummins (CMI) and Allison Transmission Holdings (ALSN)…

source from Top Penny Stocks For 2015:http://www.seekpennystocks.com/top-5-healthcare-technology-companies-to-buy-for-2015-2.html

Top 10 Medical Companies To Watch For 2014

The cost of medical care continues to rise and to be the wild card in retirement plans. Reports and studies update the estimates of the cost of retirement medical care each year. They show the cost to be high and also very unpredictable for individual retirees and couples. The studies focus on average or median costs. In your planning you have to be aware that individual costs vary greatly because of differences in personal health, geography, and insurance coverage. Your retirement medical costs can be substantially higher or lower than the overall forecasts.

We��e talking about out-of-pocket costs, those expenses that aren�� covered by Medicare. People on average incur higher medical costs than these estimates, but Medicare picks up some of the costs. These estimates are of what you��l have to pay.

A couple retiring in 2013 and incurring median drug expenses during retirement would need to save $151,000 to have a 50% chance of covering their lifetime costs for prescription drugs only, according to the latest study from the Employee Benefit Research Institute. Those who incur among the highest medicine expenses are likely to need over $220,000. The good news in the report is that the prescription drug expense estimates are lower than last year�� because of a reduction in the rate of growth of medical and drug costs.

Top Healthcare Technology Companies To Buy Right Now: Tandem Diabetes Care Inc (TNDM)

Tandem Diabetes Care, Inc., incorporated on July 1, 2008, is a medical device company with an approach to the design, development and commercialization of products for people with insulin-dependent diabetes. The Company designed and commercialized its flagship product, the t:slim Insulin Delivery System, or t:slim, based on its technology platform and consumer-focused approach. Its technology platform features Micro-Delivery Technology, a miniaturized pumping mechanism, which draws insulin from a flexible bag within the pump�� cartridge rather than relying on a syringe and plunger mechanism. The Company also applies the science of human factors to its design and development process, which seeks to optimize its devices to the intended users, allowing users to successfully operate the devices in their intended environment.

The Company developed t:slim to offer the specific features that people with insulin-dependent diabetes seek in a next-generation insulin pump. The Company designed it to have the look and feel of a modern consumer electronic device, such as a smartphone. It is the insulin pump to feature a high resolution, color touchscreen. It is also the slimmest and smallest durable insulin pump on the market, and can easily and discreetly fit into a pocket, while still carrying a cartridge with 300 units of insulin.

The Company designed its flagship product, t:slim, to have the look and feel of a modern consumer electronic device, such as a smartphone. t:slim is the slimmest and smallest durable insulin pump on the market. With its narrow profile, which is similar to many smartphones, t:slim can easily and discreetly fit into a pocket. Its technology platform allows for the use of a vivid touchscreen and easy-to-navigate software architecture, which provide users simple access to the key functions of t:slim directly from the Home Screen. Insulin pump users can quickly learn how to efficiently navigate t:slim�� software, thereby enabling healthcare providers to spend! less time teaching a person how to use the pump and more time improving management of their diabetes. Its software also features numerous shortcuts, including a simple way to return to the Home Screen and view critical information for therapy management. Its technology is specifically designed to help prevent the unintentional delivery of insulin and reduce fear associated with using a pump.

Advisors' Opinion:

• [By Paul Ausick]

  Insulin pump maker Tandem Diabetes Care Inc. (NASDAQ: TNDM) sold 8 million shares on Thursday at an IPO price of $15. The stock began trading at around $19 before closing about flat to the opening bid and then shooting up more than 13% on Friday to close at $21.84.

Top 10 Medical Companies To Watch For 2014: ImmunoCellular Therapeutics Ltd (IMUC)

ImmunoCellular Therapeutics, Ltd., incorporated on March 20, 1987, is a clinical-stage biotechnology company. The Company is engaged in developing immune-based therapies for the treatment of cancers, such as brain, ovarian and other solid tumors. Immunotherapy is an approach to treat cancer in which a patient�� own immune system is stimulated to target tumor antigens, which are molecular signals that the immune system uses to identify foreign bodies. The Company�� products include ICT-107, ICT-140, ICT-120, ICT-109 and DIAAD. ICT-107, the pipeline product, is a Phase II therapeutic dendritic cell (DC) vaccine for the treatment of glioblastoma multiforme (GBM), the common and lethal type of brain cancer. ICT-107 is designed to activate a patient�� immune system to target six different tumor-associated antigens. In February 2012, it acquired a world-wide license from the University of Pennsylvania and The John Hopkins University (JHU).

The Company in addition to ICT-107, is also developing other therapeutic DC vaccines: ICT-140 for ovarian cancer and ICT-121 for recurrent GBM. ICT-140 targets seven tumor-associated antigens expressed on ovarian cancer cells. ICT-107 is a DC vaccine that targets six different tumor-associated antigens that are found on patients��tumor cells; four of the six antigens are expressed on CSCs. The therapeutic vaccine is used subsequent to conventional therapy or concomitantly with chemotherapy in patients with newly diagnosed GBM. ICT-140 is a DC vaccine that targets seven different ovarian cancer antigens. ICT-121 is a DC vaccine that targets CD133 antigens; it has the potential to be a universal cancer vaccine because CD133 is widely expressed on CSCs from a majority of cancers. Data from this small study demonstrated that ICT-109 had a statistically ability to discriminate between cancerous and non-cancerous samples, suggesting the potential to detect pancreatic and lung cancer in plasma and serum study sets. The DIAAD (differential immunization for an! tigen and antibody discovery) platform it acquired from Molecular Discoveries utilizes immunological tolerization to accelerate the discovery of the molecular differences between diseased cells and their normal counterparts. The monoclonal antibodies produced by DIAAD provide the basis for the discovery and development of its potential diagnostic and therapeutic products.

The Company competes with Dendreon, Oncothyreon, Galena, Bavarian Nordic and Immunovaccine, Northwest Biotherapeutics, Prima Biomed, DCPrime, Roche/Genentech, Seattle Genetics, Bristol-Myers Squibb and Immunogen.

Advisors' Opinion:

• [By Smith On Stocks]

  Using my assumptions, the common of Agenus might be worth about $7.00 per share in early 2014 based on the royalties from the Glaxo vaccines and the net operating loss carry forward even if every other asset in the company were valued at zero. However, there may be substantial value in Agenus' internal vaccine programs in recurrent and newly diagnosed glioblastoma and the genital herpes vaccine. Based on a comparison to peer companies like Northwest Biotherapeutics (NWBO) and ImmunoCellular Therapeutics (IMUC), I believe that the internal programs at Agenus currently may be worth $150 million or $4.45 per share. Adding this to the value of the MAGE A-3 vaccine could produce a stock price of $11.00 in early 2014.

• [By Monica Gerson]

  ImmunoCellular Therapeutics (NYSE: IMUC) dropped 11.05% to $1.3699. ImmunoCellular's trailing-twelve-month ROE is -59.80%.

  Posted-In: market losersNews Movers & Shakers Intraday Update Markets

• [By Wallace Witkowski]

  Shares of ImmunoCellular (IMUC) �jumped after the drug developer said data on a mid-stage brain cancer drug study were looking encouraging.

• [By Lauren Pollock]

  ImmunoCellular Therapeutics Ltd.(IMUC) said its leading product candidate, a dendritic cell-based vaccine for brain cancer, didn’t show a statistically significant advantage in overall survival in a Phase II study. In a research note, Maxim Group said it is pushing its EU approval date target to 2019 and lowered its estimate on the stock to $12 a share from $18 a share. The stock plunged 62% to $1.04 premarket.

Top 10 Medical Companies To Watch For 2014: Integra LifeSciences Holdings Corp (IART)

Integra LifeSciences Holdings Corporation (Integra), incorporated on June 19, 1989, is an integrated medical technology company. Integra offers solutions in orthopedic extremity surgery, neurosurgery, spine surgery, and reconstructive and general surgery. The Company has developed numerous product lines for applications ranging from burn and deep tissue wounds to regeneration of dura mater in the brain and repair of nerve and tendon. It operates in five business segments: U.S. Neurosurgery, U.S. Extremities, U.S. Instruments, U.S. Spine and Other, and International. The International segment sells similar products to Europe, Middle East and Africa, and Central/South America, Asia-Pacific and Canada. On April 29, 2013, the Company launched the Integra Compact Cranial Closure System, which provides titanium implants for non-loadbearing (non-facial) operative cranial neurosurgical procedures. On April 30, 2013, it released its Hollywood VI intervertebral body fusion device (IBD) system. In January 2014, Integra LifeSciences Holdings Corp completed the acquisition of DuraSeal product lines from Covidien. In January 2014, Covidien PLC completed the sale of its Confluent Surgical product line to Integra LifeSciences Corporation.

U.S. Neurosurgery

The Company�� U.S. Neurosurgery sales organization sells a full line of products for neurosurgery and neuro critical care. It has products for each step of a cranial procedure and the care of the patient after surgery. Its key products include dural repair products, cerebral spinal fluid (CSF) management devices, tissue ablation equipment, intracranial monitoring equipment and cranial stabilization equipment. The Company sells equipment used in the neurosurgery operating room and neurosurgery intensive care unit (NICU).

U.S. Extremities

Extremity reconstruction includes the repair of soft tissue and the orthopedic reconstruction of bone in the foot, ankle and leg below the knee (Lower Extremity), and the hand, ! wrist, elbow and shoulder (Upper Extremity). Its key products include bone and joint fixation devices, implants and instruments for osteoarthritis, rheumatoid arthritis, wrist arthroplasty, carpel tunnel syndrome, and cubital tunnel syndrome. Other key products include its regenerative medicine devices for the treatment of acute and chronic wounds, peripheral nerve repair and protection and tendon repair, and bone graft substitutes.

U.S. Instruments

Integra�� U.S. Instruments business is a surgical instrument suppliers in the United States. Its portfolio includes over 60,000 instrument patterns and surgical products sold a range of users, including hospitals, surgery centers, and physician, dental and veterinary offices. In addition to selling hand-held instruments, it sells surgical headlight systems and table-mounted retractors. The Company�� brands include Jarit, Miltex, Padgett, Ruggles, Luxtec and Omni-Tract.

U.S. Spine and Other

Integra�� U.S. Spine and Other segment offer spinal fusion technologies that surgeons use along the full length of the spine, as well as a range of related orthobiologics. During the year ended December 31, 2012, its Spine business launched multiple new implants into the integrated interbody fusion device market and the deformity market. Its key spinal hardware products include integrated interbody fusion devices, minimally invasive solutions, and deformity correction. It markets and sells a complete line of orthobiologics, including demineralized bone products, collagen ceramic matrices and pure synthetic bone grafting solutions, to neurosurgeons, and spine, orthopedic, trauma, and foot and ankle surgeons. Integra sells its products through specialty distributors focused on its spine and orthopedic surgeon customers, as well as through some direct sales representatives. This segment also includes private-label sales of a set of its regenerative medicine technologies. Its customers are other large medical technology! companie! s that sell to end markets primarily in orthopedics and wound care.

The Company competes with Johnson & Johnson, Synthes, Inc., Stryker Corporation, Tornier, Inc., Wright Medical Group, Inc., Zimmer, Inc., Small Bone Innovations, Inc., Medtronic, Inc., Globus Medical Inc., NuVasive, Inc., Orthofix, Alphatec Spine, Inc., B. Braun Medical Inc., CareFusion and Symmetry Medical.

Advisors' Opinion:

• [By John Udovich]

  On Thursday, small cap medical device stock Integra Lifesciences Holdings Corp (NASDAQ: IART) jumped 9.90% after the FDA completed its inspection of the company's manufacturing facility which led to positive comments from analysts, meaning it might be time to take a look at its performance verses that of medical device ETFs like iShares Dow Jones US Medical Device ETF (NYSEARCA: IHI) and SPDR S&P Health Care Equipment ETF (NYSEARCA: XHE).

• [By Sean Williams]

  What: Shares of Integra LifeSciences (NASDAQ: IART  ) , a manufacturer of surgical instruments and medical implants, fell as much as 13% after the company announced a voluntary recall of certain products at its Anyasco manufacturing facility in Puerto Rico.

Top 10 Medical Companies To Watch For 2014: Receptos Inc (RCPT)

Receptos, Inc. (Receptos), incorporated on June 9, 2008, is a biopharmaceutical company. The Company is focused on discovering, developing and commercializing therapeutics for immune disorders. The Company�� product candidates span three specialty disease areas. The Company�� lead asset, RPC1063, is being developed as an oral therapy for the treatment of relapsing multiple sclerosis (RMS) and inflammatory bowel disease (IBD). Its second asset, RPC4046, is being developed for the treatment of an allergic/immune-mediated disorder, eosinophilic esophagitis (EoE), which is an orphan disease. RPC1063 is an oral, once daily, selective and potent sphingosine 1-phosphate 1 receptor (S1P1R) modulator. RPC4046 is a monoclonal antibody selective to interleukin-13 (IL-13) and produced by recombinant deoxyribonucleic acid (DNA) technology.

As of December 31, 2012, RPC1063 was being tested in the Phase II portion of an accelerated design, randomized Phase II/III study for the treatment of RMS. In addition, Receptos has obtained special protocol assessment (SPA) agreement from the United States food and drug administration (FDA) on its clinical trial design for the planned Phase III portion of the Phase II/III study, as well as a second planned RMS Phase III study. RPC1063 is also being tested in a randomized Phase II study for the treatment of ulcerative colitis (UC), a gastrointestinal (GI) disea se.

As of December 31, 2012, the Company was enrolling a randomized Phase II study evaluating the ability of RPC1063 to induce clinical remission in patients with moderately-to-severely active UC called TOUCHSTONE. The Company�� second asset, RPC4046 for the treatment of EoE, builds upon its competencies in immunology and GI diseases. In-licensed from AbbVie Bahamas Ltd. and AbbVie Inc. (AbbVie) RPC4046 is a monoclonal antibody directed against the IL-13 target, which has been validated in Asthma, a predominantly allergic/immune-mediated disorder.

Advisors' Opinion:

• [By John Udovich]

  Small cap �biopharmaceutical stock Receptos Inc (NASDAQ: RCPT) was one of the many hot biotech IPOs of last year and its also up 72.4% since the start of this year alone, meaning its time to take a closer look at this small cap stock with potential treatments for Relapsing Multiple Sclerosis (RMS) and Inflammatory Bowel Disease (IBD) along with the performance of biotech ETF benchmarks like the iShares NASDAQ Biotechnology Index ETF (NASDAQ: IBB) and SPDR S&P Biotech ETF (NYSEARCA: XBI).

Top 10 Medical Companies To Watch For 2014: Rexahn Pharmaceuticals Inc (RNN)

Rexahn Pharmaceuticals, Inc. (Rexahn) is a development-stage biopharmaceutical company. The Company focuses on the development of cures for cancer to patients worldwide. The Company�� pipeline features one drug candidate in Phase II clinical trials. The Company also has several other drug candidates in pre-clinical development. In addition, the Company has two renal cell carcinoma (CNS) candidates, Serdaxin, CNS Disorders drug for depression and neurodegenerative diseases and Zoraxel, which is a erectile dysfunction (ED) and sexual dysfunction drug that are in clinical stages and the Company is are exploring options for further development . The Company�� drug candidate, Archexin is an anticancer Akt inhibitor.

Archexin

Archexin is potent inhibitor of the Akt protein kinase (Akt) in cancer cells. Archexin has FDA orphan drug designations for five cancers (RCC, glioblastoma, and cancers of the ovary, stomach and pancreas). Multiple indications for other solid tumors can also be pursued. Archexin inhibit both activated and inactivated forms of Akt, and to reverse the drug resistance observed with the protein kinase inhibitors. Archexin is an antisense oligonucleotide (ASO) compound that is complementary to Akt mRNA, and selective for inhibiting mRNA expression and production of Akt protein. As of December 31, 2011, Archexin was in Phase II clinical trials for the treatment of pancreatic cancer with enrollment completed in September, 2011.

Serdaxin

Serdaxin is an extended release formulation of clavulanic acid, which is an ingredient present in antibiotics approved by the FDA. The Company had been developing Serdaxin for the treatment of depression and neurodegenerative disorders. From January to September, 2011, the Company conducted a randomized, double-blind, placebo-controlled study compared two doses of Serdaxin, 0.5 milligram and 5 milligram, to placebo over an eight-week treatment period for major depressive disorder (MDD) patients. As of Dec! ember 31, 2011, the Company had not made a determination of Serdaxin�� future paths or resource allocations to further develop Serdaxin to treat MDD.

Zoraxel

Zoraxel is an orally administered, on-demand tablet to treat sexual dysfunction. Zoraxel is a dual enhancer of neurotransmitters in the brain that play a key role in sexual activity phases of motivation and arousal, erection and release, and may be the ED drug to affect all three of these phases of sexual activity. As of December 31, 2011, the Company was evaluating how to proceed with the Phase IIb study of Zoraxel.

The Company�� Pre-clinical Pipeline Drug Candidates includes RX-1792, which is a small molecule anticancer EGFR inhibitor; RX-5902, which is a small molecule anticancer ribonucleic acid (RNA) helicase regulator; RX-3117, which is a Small molecule anticancer deoxyribonucleic acid (DNA) synthesis Inhibitor; RX-8243, which is a small molecule anticancer aurora kinase inhibitor; RX-0201-Nano, which is a nanoliposomal anticancer Akt inhibitor; RX-0047-Nano, which is an nanoliposomal anticancer HIF-1 alpha inhibitor and RX-21101, which is a nano-polymer Anticancer.

Advisors' Opinion:

• [By James E. Brumley]

  At first glance, Rexahn Pharmaceuticals, Inc. (NYSEMKT:RNN) doesn't look like anything particularly trade-worthy. The stock's now where it was in late October, and where it was in late September, and even where it was in late June. In other words, though RNN has been much higher and much lower than its current price of $0.46 over the course of the past several months, it doesn't look like it's going anywhere - on a net basis - anytime.

• [By James E. Brumley]

  With just a quick glance at a chart of Rexahn Pharmaceuticals, Inc. (NYSEMKT:RNN), it would be easy to conclude it's nothing but a volatile mess. When you take a step back and look at a long-term weekly chart of RNN, however, it starts to become clear that this small cap biopharma name is on the verge of a monster-sized breakout. First things first, however.

• [By James E. Brumley]

  If you were lucky enough to step into Rexahn Pharmaceuticals, Inc. (NYSEMKT:RNN) when your truly suggested it was a budding buy back on December 23rd, then congratulations - you're now up a little more than 60% (assuming you bought into RNN after the break above a key resistance line on the 27th). Now get out. Instead, use your profits from the Rexahn to take on a stake in GTx, Inc. (NASDAQ:GTXI). No, GTXI may not look like much at first, but when you take a step back and look at a chart of GTx, Inc. through a longer-term lens, the upside potential becomes clear.

Top 10 Medical Companies To Watch For 2014: Protalix Biotherapeutics Inc (PLX)

Protalix BioTherapeutics, Inc. is a biopharmaceutical company focused on the development and commercialization of recombinant therapeutic proteins based on its ProCellEx protein expression system, ProCellEx. Using its ProCellEx system, the Company is developing a pipeline of biosimilar or generic versions of recombinant therapeutic proteins based on its plant cell-based expression technology, which focuses pharmaceutical markets and that rely upon known biological mechanisms of action. ProCellEx protein expression system consists of a set of technologies and capabilities for the development of recombinant proteins, including advanced genetic engineering technology and plant cell-based protein expression methods. Its ProCellEx protein expression system is built on flexible custom-designed bioreactors made of polyethylene and optimized for the development of complex proteins in plant cell cultures. In June 2010, it had completed the preliminary phase I clinical trial of PRX-105.

Taliglucerase Alfa

Taliglucerase alfa is a plant cell expressed recombinant glucocerebrosidase enzyme (GCD) for the treatment of Gaucher disease. The Company has commenced pre-clinical studies of an oral form of taliglucerase alfa. Its oral taliglucerase alfa is a plant cell expressed form of GCD that is naturally encapsulated within carrot cells genetically engineered to express the GCD enzyme. Pre-clinical studies of oral taliglucerase alfa demonstrate the stability of the enzyme in the cell and the capacity of the cell�� cellulose wall to protect the enzyme against degradation in the digestive tract in an in-vitro model of the stomach and intestines. Additionally, rats fed with lyophilized carrot cells expressing GCD have accumulated the active enzyme in the target organs; the spleen and liver. As of December 31, 2010, the Company had completed Phase III Clinical Trial.

PRX-102

The Company is developing PRX-102, its plant cell expressed modified version of the recombinant ! alpha-GAL-A protein, a therapeutic enzyme for the treatment of Fabry disease. Fabry disease is a rare, hereditary, genetic lysosomal storage disorder in humans caused by an X-lined deficiency of the alpha-GAL-A enzyme. The Company is in the animal evaluation testing phase of the development of PRX-102, which tests are based on a mouse model for Fabry disease.

Acetylcholinesterase

Protalix Ltd. is a wholly owned subsidiary of the Company is licensed the rights to certain technology under a research and license agreement with Yissum Research and Development Company (Yissum) and the Boyce Thompson Institute, Inc. Pursuant to the agreement, the Company is developing PRX-105, a plant cell-based acetylcholinesterase (AChE) and its molecular variants for the use in several therapeutic and prophylactic indications, as well as in a biodefense program and an organophosphate-based pesticide treatment program.

As of December 31, 2010, its in-vitro experiments of PRX-105 have shown that the acetylcholinesterase enzyme in its ProCellEx protein expression system demonstrates biological activity on biochemical and cellular levels. In addition, early animal studies demonstrated that the acetylcholinesterase expressed in its ProCellEx protein expression system was able to treat animals exposed to the nerve gas agent analogues, both when injected with its acetylcholinesterase product candidate immediately before exposure or when injected after exposure. In March 2010, it initiated a preliminary phase I clinical trial of PRX-105, which the Company completed in June 2010.

pr-antiTNF

pr-antiTNF is a candidate for the treatment of certain autoimmune diseases such as rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing, spondylitis, psoriatic arthritis and plaque psoriasis. The Company has designed the antiTNF as pr-antiTNF. pr-antiTNF is a plant cell-expressed recombinant fusion protein made from the soluble form of the human TNF receptor (TNFR), f! used to t! he Fc component of a human antibody domain. pr-antiTNF has an identical amino acid sequence to Enbrel and its in-vitro and preclinical animal studies have demonstrated that pr-antiTNF exhibits similar activity to Enbrel. Specifically, pr-antiTNF binds TNF thereby inhibiting it from binding to cellular surface TNF receptors and protects L929 cells from TNF-induced apoptosis in a dose-dependent manner.

The Company competes with Genzyme, Actelion, Crucell N.V., Biolex, Inc., Chlorogen, Inc., Greenovation Biotech GmbH, Symbiosys, Novartis AG/Sandoz Pharmaceuticals, BioGeneriX AG, Stada Arzneimittel AG, BioPartners GmbH and Teva.

Advisors' Opinion:

• [By Keith Speights]

  Other investors might wish that Pfizer would use some of its cash to acquire a few smaller companies. Protalix BioTherapeutics (NYSEMKT: PLX  ) has been mentioned as one possible candidate. The two companies already partner together on Gaucher disease drug Elelyso. In February, Protalix spurred rumors that Pfizer could be interested in buying the company after it announced that it had engaged Citigroup to pursue a "broad array of strategic alternatives."

• [By Maxx Chatsko]

  Industrial biotech isn't the only industry headed to Brazil. Protalix (NYSEMKT: PLX  ) entered into a technology transfer agreement with Brazil's Ministry of Health last week that will pay the company $280 million. The deal is big news for Protalix's first product, Elelyso/Uplyso, which was developed with partner Pfizer (NYSE: PFE  ) . The treatment is approved as an enzyme replacement therapy, or ERT, for adults with type 1 Gaucher disease, and it marks a huge step forward for the future of biomanufacturing. In the following video, Fool contributor Maxx Chatsko explains what this means for the product's commercialization and the adoption of Protalix's novel plant cell-based expression system for therapeutic proteins.

Top 10 Medical Companies To Watch For 2014: Stemline Therapeutics Inc (STML)

Stemline Therapeutics, Inc. (Stemline), incorporated on August 8, 2003, is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics that target both cancer stem cells (CSCs) and tumor bulk. The Company is developing two clinical-stage product candidates, SL-401 and SL-701, for which it holds global marketing rights. The indication for SL-401, a biologic-drug conjugate, is acute myeloid leukemia (AML). The indications for SL-701, a synthetic peptide vaccine, are pediatric and adult brain cancer. It has a platform, StemScreen, for the discovery of CSC-targeted compounds, from which it has discovered or validated several of its clinical and preclinical product candidates. Stemline�� StemScreen consists of StemScreen-1 and StemScreen-2 for the identification of CSC-directed compounds.

SL-301 is a small molecule gamma-secretase inhibitor that inhibits Notch, a pathway expressed by CSCs and tumor bulk of multiple cancer types. SL-101 is a monoclonal antibody-based (mAb -based) compound that targets CD123 and has shown in vitro activity against certain hematologic cancers. SL-201 is a small molecule active against certain hematologic and solid tumor types. SL-601 is a mAb-based compound that targets a cell surface marker on bladder CSCs, which is also expressed on a variety of other solid tumor types. It has also in-licensed certain intellectual property directed to mAb-based therapeutics to validated oncology targets, including Glypican-3, Tie-1, CD133, Frizzled, Smoothened and Patched.

SL-401 - An IL-3R-Directed Compound Targeting Cancer Stem Cells and Tumor Bulk

SL-401 is a clinically active biologic-drug conjugate consisting of human interleukin-3 (IL-3) genetically linked to a truncated version of diphtheria toxin. SL-401 targets the IL-3 receptor (IL-3R), which is overexpressed on both the CSCs and tumor bulk of multiple hematologic cancers, including AML. SL-401 has demonstrated preclinical in vit! ro and in vivo activity against both leukemia blasts (which includes tumor bulk) and CSCs of a range of human leukemia cell lines and primary leukemia cells from patients.

SL-701

SL-701 is a clinically active synthetic peptide vaccine that targets several epitopes on CSCs and tumor bulk of brain cancer. In two completed Phase 1/2 clinical trials, SL-701 demonstrated single agent anti-tumor activity in pediatric patients with newly diagnosed brainstem glioma (BSG) and other high-grade gliomas (HGGs) and in adult patients with refractory or recurrent GBM, and other HGGs.

StemScreen-1

StemScreen-1 is a drug discovery platform designed to identify CSC-targeted compounds based on the isolation of CSCs and evaluation of CSC gene expression profiles. CSCs are isolated from primary tumor tissue or cell lines, and then subjected to gene expression analysis using a variety of technologies, including microarray. A control tissue, such as normal bone marrow is analyzed as a comparator against the gene expression profile of the isolated CSCs. These data are then interfaced with an information base of compounds and their mechanisms of action (that is which gene products and pathways they impact). It has utilized StemScreen-1 to discover a number of its preclinical drug candidates. These include SL-201, SL-301, and SL-601. In addition, SL-401 demonstrated activity against CSCs as determined by both an in vitro colony formation and in vivo animal implantation assay, thereby validating certain StemScreen-1 anti-CSC assays.

StemScreen-2

StemScreen-2 is a high throughput drug discovery platform it is developing to discover anti-CSC compounds. StemScreen-2 utilizes a cell-based assay that can track and follow CSCs in their natural state during high throughput screening. In particular, StemScreen-2 utilizes a CSC-specific promoter linked to a reporter as a method for identifying and following CSCs in their native environment of surrounding tumor b! ulk. In t! his way, StemScreen-2 enables the identification of compound hits, in a high throughput manner, with anti-CSC activity.

The Company competes with Boston Biomedical, Inc., Eclipse Therapeutics, Inc., OncoMed Pharmaceuticals, Inc., Verastem, Inc., Astellas Pharma US, Inc., Boehringer Ingelheim GmbH, Dainippon Sumitomo Pharma Co. Ltd., Geron Corp., GlaxoSmithKline plc, ImmunoCellular Therapeutics, Ltd, Macrogenics Inc., Amgen, Inc., Pfizer Inc., Roche Holding AG, Sanofi U.S. LLC., Cyclacel Pharmaceuticals, Inc., Sunesis Pharmaceuticals Inc., Clavis Pharma ASA, Ambit Biosciences Corporation, Celgene Corporation, Eisai Co. Ltd., Celator Pharmaceuticals, Inc., Merck & Co., Inc., Eisai Co., Inc., Roche Holding AG, Novartis AG and Celldex Therapeutics, Inc.

Advisors' Opinion:

• [By Jay Silverman]

  Some of the biggest leaders in that field, and there have been dozens in fields, if not more this year, such as Bluebird (BLUE) and Stemline Therapeutics (STML) and have all pulled back to significantly lower levels; even below, in Bluebird's case, the price that had actually opened up as an IPO, even though it's above its IPO price.