ALN-TTRsc is a ribo nucleic acid interference (RNAi) therapeutic targeting the transthyretin (TTR) gene that is being developed for the treatment of TTR-mediated amyloidosis (ATTR).
Results from the study revealed that ALN-TTRsc was successful in reducing serum TTR protein levels to more than 80% in healthy volunteers who were enrolled in the study. The recent study results were at par with the previously reported ALN-TTRsc results in non-human primates.
Results from the phase I study further revealed that ALN-TTRsc was generally safe and well tolerated. The randomized, double-blind, placebo-controlled, single- and multi-dose, dose-escalation study is still ongoing. Alnylam will assess the safety and tolerability of the candidate (single or multiple ascending subcutaneous doses) along with other parameters like assessment of clinical activity of the candidate as measured by serum TTR levels.
Top Wireless Telecom Stocks For 2015: Natura Cosmeticos SA (NATU3)
Natura Cosmeticos SA is a Brazil-based company that, together with its subsidiaries, is engaged in the manufacture, industrialization, distribution and commercialization of cosmetics, fragrances and personal hygiene products under the brand name Natura. The Company's product line includes deodorants, makeup, sunscreens, lotions, creams, lipsticks and perfumes, among others. It operates in Chile, Peru, Argentina, Mexico, Colombia, Spain and Netherlands, among others, and, as of December 31, 2011, the Company had such subsidiaries as Industria e Comercio de Cosmeticos Natura Ltda, Natura Cosmeticos SA, Natura Cosmeticos de Mexico SA de CV, Natura Cosmeticos Espana SL, Natura (Brasil) International BV and Natura Inovacao e Tecnologia de Produtos Ltda, among several others. On February 28, 2013, the Company concluded the acquisition of a 65% stake in Emeis Holdings Pty Ltd, operating under Aesop brand. Advisors' Opinion:- [By Harry Suhartono]
Brazil�� Ibovespa rose for a third day as traders pared bets on higher borrowing costs in Brazil, boosting the outlook for companies that sell in the local market. B2W Cia. Digital led gains among retailers, with Lojas Americanas SA (LAME3) and Natura Cosmeticos SA (NATU3) also trading higher. Petrochemicals producer Braskem SA (BRKM5) was the worst performer on the equity gauge after O Estado de S.Paulo reported Petroleo Brasileiro SA (PETR4) is seeking to raise prices of naphtha sold to the company by 5 percent.
Best Gas Utility Companies To Own In Right Now: Cadus Corp (KDUS)
Cadus Corporation (Cadus), incorporated in January 23, 1992, has a wholly owned subsidiary, Cadus Technologies, Inc. (the Subsidiary), which holds all patents, patent applications, know how, licenses and drug discovery technologies of the Company. The Company maintains all its strains, as well as a biological database that catalogues its collection of cells, cell lines, yeast strains and genetic engineering tools. This database has approximately 30,000 entries, which include the phenotype and the genotype of the cell or yeast strain and its storage site. As of December 31, 2011, the Company had no internal or external drug discovery operations.
Yeast
The Company has developed technologies based on yeast that are useful in identifying drug discovery candidates targeted at G Protein-coupled receptors. Yeast is a single-celled microorganism that is used to make bread, beer and wine. Both yeast and human cells consist of a membrane, an intracellular region and a nucleus containing genes. The genes in yeast express proteins, including cell-surface receptors, such as G Protein-coupled receptors and signaling molecules, such as protein kinases, that are similar to human proteins.
Hybrid Yeast Cells
The Company developed a technology to insert human genes into yeast cells to create hybrid yeast cells. Its scientists created hybrid yeast cells by replacing yeast G Protein-coupled receptor genes and certain signaling molecules with their human equivalents. As a result, these hybrid yeast cells express a human G Protein-coupled receptor and a portion of its signaling pathway. These hybrid yeast cells can be used to identify those compounds that act as agonists or antagonists to that receptor or a molecule that is in its signaling pathway. The Company designed and developed more than 25 thousand genetically different yeast strains that can be used to build hybrid yeast cells (the Yeast System).
The Company competes with Glaxo Smith Kline, Plc.
Advisors' Opinion:- [By Geoff Gannon] cash producing business like ADDvantage (AEY) that happens to be overcapitalized. I'd much rather own a business with real earnings rather than wait for something to happen with a pile of cash.
My question is this: How cheap is cheap enough? Clearly (to me), George Risk (RSKIA) is cheap at or even just above book value. It's a darn good business so I'm getting high quality assets and earnings power. That gets less clear when looking at lower quality businesses.
For example:
Solitron (SODI) sells at 74% of NCAV, has decent z- and f-scores, a FCF margin of 5.3% and an ROA of 12%.
Best Gas Utility Companies To Own In Right Now: Great Plains Energy Inc (GXP)
Great Plains Energy Incorporated (Great Plains Energy), incorporated on February 26, 2001, is a public utility holding company. The Company does not own or operate any assets other than the stock of its subsidiaries. Great Plains Energy�� wholly owned direct subsidiaries with operations or active subsidiaries includes Kansas City Power & Light Company (KCP&L), and KCP&L Greater Missouri Operations Company (GMO). The Company is engaged in the business segment of electric utility. The electric utility segment consists of KCP&L, a regulated utility, and GMO�� regulated utility operations, which include its Missouri Public Service and St. Joseph Light & Power (L&P) divisions. Electric utility serves approximately 825,300 customers located in western Missouri and eastern Kansas.
KCP&L is an integrated, regulated electric utility that provides electricity to customers in the states of Missouri and Kansas. KCP&L has one active wholly owned subsidiary, Kansas City Power & Light Receivables Company (Receivables Company). GMO is an integrated, regulated electric utility that provides electricity to customers in the state of Missouri. GMO also provides regulated steam service to certain customers in the St. Joseph, Missouri area. GMO wholly owns MPS Merchant Services, Inc. (MPS Merchant), which has certain long-term natural gas contracts remaining from its former non-regulated trading operations.
Customers include approximately 726,100 residences, 96,600 commercial firms, and 2,600 industrials, municipalities and other electric utilities. During the year ended December 31, 2012, electric utility�� retail revenues averaged approximately 90% of its total operating revenues. Wholesale firm power, bulk power sales and miscellaneous electric revenues accounted for the remainder of electric utility�� revenues. During 2012, electric utility�� total electric revenues were 100% of Great Plains Energy�� revenues. During 2012, electric utility�� net income accounted for approximately! 108%, of Great Plains Energy�� income from continuing operations, respectively.
Advisors' Opinion:- [By Eric Volkman]
Great Plains Energy (NYSE: GXP ) is keeping its dividend as level as the geographical feature in its company name. The company will distribute $0.2175 per share of its common stock on June 20 to shareholders of record as of May 20.� This amount matches the company's previous two disbursements, the most recent of which was paid in March. Before that, Great Plains handed out $0.2125.
- [By Justin Loiseau]
As coal prices regain their competitive edge, investors should watch TECO Energy (NYSE: TE ) , Great Plains Energy (NYSE: GXP ) , and FirstEnergy (NYSE: FE ) .
- [By David Dittman]
Question: It�� not a popular name, but what are your thoughts on Great Plains Energy Inc (NYSE: GXP) with regard to dividend hikes and price?
Answer: I have Great Plains Energy rated ��old��right now. But 100 percent of revenue is regulated–i.e., predictable and stable–and 2013 earnings growth was outstanding due to a resurgent regional economy.
- [By David Dittman]
Answer: It’s too soon to say what the financial impact of the Winnipeg incident will have on TransCanada. The impact for its customers, including Xcel Energy (NYSE: XEL) and Great Plains Energy (NYSE: GXP), may be more acute in the short term. TransCanada will definitely be under increased regulatory scrutiny.
I’m a fan of TransCanada for the long term. It has a solid, diverse and growing presence in North American energy infrastructure. It’s about much more than Keystone XL.
Best Gas Utility Companies To Own In Right Now: Linktone Ltd.(LTON)
Linktone Ltd., through its subsidiaries, provides entertainment-oriented telecom value-added services and content to mobile phone users over mobile telecommunications networks in China and Indonesia, as well as the 3G mobile telecommunications network in Indonesia. The company specializes in the development, aggregation, marketing, and distribution of user wireless content and applications for access by mobile phone users through three mobile network operators in China and nine mobile network operators in Indonesia. Its 2G short messaging service (SMS)-based services include ringtones, icons and screen savers, interactive SMS messaging in certain television programs, adventure, action, trivia and fortune-telling games, lunar and Western horoscopes, jokes, fan clubs, and event-driven or entertainment news updates. The company?s 2.5G services comprise multimedia messaging services, such as animated cartoons and screensavers, comic strips, magazine-style ?mobile articles? on various topics, and event-driven news updates; and WAP services, which consist of WAP-based ringtones, screensavers, games and dating services, and advanced Java games. It also offers audio-related services, including color ring-back tones; and interactive voice response services that allow users to listen to songs, jokes, stories, and coverage of various events. In addition, Linktone is launching 3G services in Indonesia, including e-paper/e-reading; video-on-demand on tablet devices and smart TVs; and radio streaming on mobile applications. Further, it distributes and sells home entertainment products, such as VCDs/DVDs/Blu-ray discs and video-on-demand in Singapore, Malaysia, and Indonesia; and engages in the theatrical distribution of movies, karaoke video licensing, karaoke system rental, and providing a karaoke-on-demand channel on Pay TV platforms. The company was founded in 1999 and is based in Shanghai, China. Linktone Ltd. is a subsidiary of MNC International Li mited.
Advisors' Opinion:- [By Lisa Levin]
Linktone (NASDAQ: LTON) shares touched a new 52-week low of $1.30. Linktone's trailing-twelve-month operating margin is -20.15%.
TOR Minerals International (NASDAQ: TORM) shares touched a new 52-week low of $9.76. TOR Minerals shares have dropped 9.95% over the past 52 weeks, while the S&P 500 index has gained 27.45% in the same period.
Best Gas Utility Companies To Own In Right Now: iShares iBoxx $ Investment Grade Corporate Bond ETF (LQD)
iShares iBoxx $ InvesTop Investment Grade Corporate Bond Fund, formerly known as iShares GS $ InvesTop Corporate Bond Fund, seeks investment results that correspond generally to the price and yield performance of the corporate bond market as defined by the iBoxx $ Liquid Investment Grade Index (formerly the GS $ InvesTop Index) (the Index). The Fund invests in a representative sample of the securities in the Index, which has a similar investment profile as the Index.
The Index measures the performance of a fixed number of highly liquid investment-grade corporate bonds. The Index is a rules-based index consisting of up to 100 highly liquid, investment-grade, United States dollar-denominated corporate bonds that seek to maximize liquidity while maintaining representation of the corporate bond market. The Fund's investment advisor is Barclays Global Fund Advisors.
Advisors' Opinion:- [By Chuck Saletta]
Where to invest?
Domestic stocks. The Vanguard Total Market (NYSEMKT: VTI ) ETF is a one-stop-shop that gives you access to around 99.5% by market cap of the publicly held U.S. stocks traded on major exchanges. A mere 3% turnover and microscopically low 0.05% expense ratio makes this a low-cost way to invest in the overall stock market. Investment-grade bonds. The iShares iBoxx $Invest Grade Corp Bond � (NYSEMKT: LQD ) ETF owns nearly $24 billion worth of investment-grade corporate bonds. A small 4% turnover and low 0.15% expense ratio make this a low-cost way to get bond exposure. Real estate. The SPDR Dow Jones REIT (NYSEMKT: RWR ) ETF has a bit over $2 billion invested in real estate investment trusts, attempting to match the Dow Jones Select REIT index. With a reasonable 7% turnover and a still pretty low 0.25% expense ratio, this is a reasonable way to get real estate exposure without turning yourself into a landlord. Foreign stocks. Vanguard's Total International Stock Index (NASDAQ: VXUS ) ETF has nearly $90 billion in foreign stocks under its control, owning pieces of more than 6,100 stocks from 45 countries. With a mere 3% turnover and low 0.16% expense ratio, it's one of the lowest-cost ways to get your hands on foreign companies without being an international accounting expert. Inflation-protected government bonds. The iShares Barclays TIPS Bond (NYSEMKT: TIP ) ETF has around $20 billion invested in U.S. Treasury inflation-protected bonds. With a low expense ratio of 0.2% and a reasonable 10% turnover rate, it's a decent way to get exposure to inflation-protected bonds. Note, though, that
There are countless possibilities for building your retirement portfolio to cover Social Security's gap, depending on your personal risk tolerance, timeline, and need for cash. Here are decent index-style ETFs across various asset types to consider when building your plan: - [By Eric Mancini]
A good example of this low duration advantage is 2013. The U.S. investment grade bond index, with the I-Shares Iboxx ETF (NYSE: LQD) as a reference, was down 2.2 percent on a total return basis, while the Chinese renminbi-denominated investment grade index, using the Power Shares Chinese Dim Sum ETF (NYSE: DSUM) as the proxy, was up 6.3 percent!
Best Gas Utility Companies To Own In Right Now: Douglas Emmett Inc. (DEI)
Douglas Emmett, Inc., a real estate investment trust, owns and operates office and multifamily properties in California and Hawaii. As of December 31, 2007, the company�s office portfolio consisted of 48 properties and multifamily portfolio consisted of 9 properties. Its properties are located in Brentwood, Olympic Corridor, Century City, Beverly Hills, Santa Monica, Westwood, Sherman Oaks/Encino, Warner Center/Woodland Hills, and Burbank submarkets of Los Angeles County, California, as well as in Honolulu, Hawaii. The company is headquartered in Santa Monica, California.
Advisors' Opinion:- [By Monica Gerson]
Breaking news
NASDAQ OMX Group (Nasdaq: NDAQ) and Borsa Istanbul A.S. have today concluded a wide-ranging agreement, which includes the delivery of market-leading technologies and advisory services to Borsa Istanbul, and NASDAQ OMX taking an equity stake in Borsa Istanbul. To read the full news, click here. Acacia Research (NASDAQ: ACTG) announced today that its Bolt MRI Technologies LLC subsidiary has entered into an agreement with Fonar Corporation (NASDAQ: FONR). To read the full news, click here. Douglas Emmett, (NYSE: DEI) announced that William Kamer will be retiring from full time service as its Chief Investment Officer effective January 31, 2014. Mr. Kamer will continue to be employed by Douglas Emmett as a Senior Advisor. To read the full news, click here. Acacia Research (NASDAQ: ACTG) announced today that its Brandywine Communications Technologies LLC subsidiary has entered into a settlement and patent license agreement with Alcatel-Lucent USA (NYSE: ALU). To read the full news, click here.Posted-In: Benchmark US Stock FuturesNews Eurozone Futures Global Pre-Market Outlook Markets
- [By Rich Duprey]
Office and multifamily housing operator�Douglas Emmett� (NYSE: DEI ) �announced yesterday�its second-quarter dividend of $0.18 per share, the same rate it's paid for the last two quarters after raising the payout 20% from $0.15 per share.
- [By Marc Bastow]
High-quality office and multi-family real estate investment trust Douglas Emmett (DEI) raised its quarterly dividend 11% to 20 cents per share, payable on Jan. 15 to shareholders of record as of Dec. 30.
DEI Dividend Yield: 3.38%
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